Opioid peptides modulate production of interferon γ by human mononuclear cells

Brown, Sharon L.; Epps, Dennis E. Van

doi:10.1016/0008-8749(86)90064-x

Cited by 114 publications

(28 citation statements)

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“…In addition the assay systems used by the various authors differ with respect to the mitogenic stimulus used (Con A versus PHA) as well as the source of the lymphocytes (murine splenocytes versus human peripheral blood lymphocytes). Brown and Van Epps (1986), who determined the influence of PE l-3 1 on IFN-?I production by lymphocytes, also reported that this peptide could either enhance or inhibit the response depending on the donor used, when applied in physiolog-ical doses. It might be of interest to take into account the results of Class and van Rood (1985) who reported that dtyE (PE2-17) may interact preferentially with certain HLA class I antigens II;15,22,.…”

Section: Reproducibility Of the Modulatory Action Of P-endorphinmentioning

confidence: 99%

“…The neuropeptide /3E has been shown to enhance monocyte, lymphocyte, and neutrophil migration (Van Epps & Salan, 1984) and to increase NK cell function (Kay, Allen, Morley, 1984) as well as the production of interferon-y (IFN-y) (Brown & Van Epps, 1986). Alvarez-Mon, Kehrl, and Fauci (1985) have demonstrated that ACTH can enhance the mitogen-induced immunoglobulin production of human tonsillar B lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of the immune response by POMC-derived peptides

Heijnen

Zijlstra

Kavelaars

et al. 1987

Brain, Behavior, and Immunity

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The POMC-derived peptides (5endorphin and ACTH are capable of modulating an immune response in physiological concentrations. These neuropeptides can either enhance or inhibit the proliferative response of human peripheral blood lymphocytes after stimulation with the mitogen concanavalin A. The modulatory action of the peptides is not only dependent on the concentration but appears to be donor dependent. The response pattern observed is not determined by a selective affinity for certain amino acid sites on the molecules with "enhancing" or "inhibiting" activities. since fragments of P-endorphin and ACTH also produce a differential donor-dependent response pattern.

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Section: Reproducibility Of the Modulatory Action Of P-endorphinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modulation of the immune response by POMC-derived peptides

Heijnen

Zijlstra

Kavelaars

et al. 1987

Brain, Behavior, and Immunity

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“…These effects are assumed to be due to mechanisms which are not classical opioid receptor mediated. For example, Brown and Van Epps [37] showed that both β-endorphin and met-enkephalin elevated IFN-γ production by Concanavalin A (ConA)-stimulated human peripheral blood mononuclear cells (PBMCs), but the increase in IFN-γ production was not reversible by the opioid antagonist naloxone. Further, Mandler et al [38] also found that β-endorphin increased IFN-γ production from phytohemagglutinin (PHA)-stimulated human lymphocytes, and this effect was partially reversed with naloxone.…”

Section: Introductionmentioning

confidence: 99%

Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression

Finley¹,

Happel²,

Kaminsky³

et al. 2008

Cellular Immunology

119

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Opioids were originally discovered because of their ability to induce analgesia, but further investigation has shown that the opioids regulate the function of cells involved in the immune response. We suggest that the regulation of cytokine, chemokine, and cytokine receptor expression is a critical component of the immunomodulatory activity of the opioids. In this paper we review the literature dealing with the regulation of cytokine and cytokine receptor expression by agonists for the three major opioid receptor types (μ, κ, and δ), and nociceptin, the natural agonist for the orphanin FQ/nociceptin receptor. Although the opioid receptors share a high degree of sequence homology, opposing roles between the kappa opioid receptor (KOR) and the mu opioid receptor (MOR) have become apparent. We suggest that activation of the KOR induces an anti-inflammatory response through the down-regulation of cytokine, chemokine and chemokine receptor expression, while activation of the MOR favors a pro-inflammatory response. Investigation into the opioid receptorlike (ORL1)/nociceptin system also suggests a role for this receptor as a down-regulator of immune function. These effects suggest a broad role for opioids in the modulation of the function of the immune system, and suggest possible targets for the development of new therapeutics for inflammatory and infectious diseases.

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“…In vitro studies have shown that both opioids and naloxone, an opioid receptor antagonist, may modulate mitogen-induced PBMCs (25), splenocyte proliferation (26,27), NK cell activity (28,29), and production of inflammatory (30)(31)(32) and immunoregulatory cytokines (17,(33)(34)(35). In vivo evidence of the regulatory immune functions of MOR activators has also been reported in several animal models of autoimmune (36,37) and inflammatory diseases (38)(39)(40).…”

mentioning

confidence: 97%