Cell Reports volume 4, issue 3, P504-515 2013 DOI: 10.1016/j.celrep.2013.07.002 View full text
George Shapovalov, Dimitra Gkika, Maily Devilliers, Artem Kondratskyi, Dmitri Gordienko, Jerome Busserolles, Alexandre Bokhobza, Alain Eschalier, Roman Skryma, Natalia Prevarskaya

Abstract: Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabilitation. Unsurprisingly, OPRMs have been a central point of many studies. Nonetheless, a satisfactory understanding of the pathways leading to distorted sensory responses during opiate administra…

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