Opiate treatment for opiate withdrawal in newborn infants

Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004–2011

“…The use of opioids for opioid withdrawal is a practice recommended by the AAP 7,32 and supported by a recent Cochrane review. 8 Still, we found that 14% of centers primarily utilize phenobarbital, similar to previous reports. 9 Variations in practice 33 and outcomes 34,35 have been described in other studies of neonates and its presence suggests that further improvements need to be made to improve care delivered to this vulnerable population.…”

Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004–2011

“…The use of opioids for opioid withdrawal is a practice recommended by the AAP 7,32 and supported by a recent Cochrane review. 8 Still, we found that 14% of centers primarily utilize phenobarbital, similar to previous reports. 9 Variations in practice 33 and outcomes 34,35 have been described in other studies of neonates and its presence suggests that further improvements need to be made to improve care delivered to this vulnerable population.…”

Substitution therapy of infants for addiction and withdrawal. Possible links to sudden infant death (SID). Literature review and case reports

“…Ebner et al [49] found the mean duration from birth to withdrawal requiring treatment was 33 h for morphine, 34 h for buprenorphine and 58 h for methadone. A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51].…”

“…A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51]. Lejeune et al [52] investigated 246 cases with methadone or buprenorphine treatment with the effects being similar for methadone and high dose buprenorphine.…”

Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates

“…The effectiveness and safety of opiate treatment in newborn infants was explored recently in a Cochrane Review, which concluded that opiates are the preferred initial therapy for NAS, particularly for the infants of mothers using opioids during pregnancy [115,116]. A number of reports highlight the utility of morphine in this respect.…”

Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004–2011

“…The use of opioids for opioid withdrawal is a practice recommended by the AAP 7,32 and supported by a recent Cochrane review. 8 Still, we found that 14% of centers primarily utilize phenobarbital, similar to previous reports. 9 Variations in practice 33 and outcomes 34,35 have been described in other studies of neonates and its presence suggests that further improvements need to be made to improve care delivered to this vulnerable population.…”

Substitution therapy of infants for addiction and withdrawal. Possible links to sudden infant death (SID). Literature review and case reports

“…Ebner et al [49] found the mean duration from birth to withdrawal requiring treatment was 33 h for morphine, 34 h for buprenorphine and 58 h for methadone. A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51].…”

“…A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51]. Lejeune et al [52] investigated 246 cases with methadone or buprenorphine treatment with the effects being similar for methadone and high dose buprenorphine.…”

Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates

“…The effectiveness and safety of opiate treatment in newborn infants was explored recently in a Cochrane Review, which concluded that opiates are the preferred initial therapy for NAS, particularly for the infants of mothers using opioids during pregnancy [115,116]. A number of reports highlight the utility of morphine in this respect.…”

Variation in treatment of neonatal abstinence syndrome in US Children's Hospitals, 2004–2011

“…The use of opioids for opioid withdrawal is a practice recommended by the AAP 7,32 and supported by a recent Cochrane review. 8 Still, we found that 14% of centers primarily utilize phenobarbital, similar to previous reports. 9 Variations in practice 33 and outcomes 34,35 have been described in other studies of neonates and its presence suggests that further improvements need to be made to improve care delivered to this vulnerable population.…”

Substitution therapy of infants for addiction and withdrawal. Possible links to sudden infant death (SID). Literature review and case reports

“…Ebner et al [49] found the mean duration from birth to withdrawal requiring treatment was 33 h for morphine, 34 h for buprenorphine and 58 h for methadone. A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51].…”

“…A meta-analysis by Osborn et al [50] points into the same direction with opiates vs. phenobarbitone showing no significant difference in failure. While opiate treatment may be restricted to infants of mothers using opiates it appears to reduce the time to regain birth weight [51]. Lejeune et al [52] investigated 246 cases with methadone or buprenorphine treatment with the effects being similar for methadone and high dose buprenorphine.…”

Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates

“…The effectiveness and safety of opiate treatment in newborn infants was explored recently in a Cochrane Review, which concluded that opiates are the preferred initial therapy for NAS, particularly for the infants of mothers using opioids during pregnancy [115,116]. A number of reports highlight the utility of morphine in this respect.…”