Ophthalmic Manifestations of Newly Diagnosed Acute Leukemia Patients in a Tunisian Cohort

Sayadi, Jihene; Gouider, Dhouha; Allouche, Yasmine; Choura, Racem; Cherni, Ines; Sayadi, Malek; Benneji, Hend; Zghal, Imene; Malek, Ines; Nacef, Leila

doi:10.2147/opth.s365648

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Bilateral or mono-lateral serous detachment of the retina is associated with diffuse infiltration of leukemic cells within and surrounding choroidal vessels [ 49 , 50 ]. Possibly, blood stagnation or mechanical compression of choroidal vessels results in ischemia of the overlying retinal pigment epithelium and disruption of the intercellular tight junctions [ 50 , 51 ].…”

Section: Secondary Disease Involvementmentioning

confidence: 99%

Ophthalmic Manifestations in Patients with Blood Malignancies

Rossi,

Buizza,

Alessio

et al. 2024

Hematology Reports

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Ocular complications can occur in up to 90% of patients with blood malignancies. Such complications range from direct infiltration to local hemostatic imbalance and treatment-related toxicity. This narrative review is based on a systematic computerized search of the literature conducted until January 2024 and examines the common ocular complications associated with blood cancers. Ocular complications from primary disease include mass effects from ocular adnexal lymphomas and intraocular lymphomas, with B-cell lymphomas accounting for 95% of primary ocular presentations. Secondary disease involvement from systemic hematological malignancies can lead to a wide range of ocular manifestations, such as leukemic retinopathy. Furthermore, toxicity from antineoplastic therapies and ocular graft versus host disease (oGVHD) after hematopoietic stem cell transplantation present additional risks to ocular health. In conclusion, ocular complications in blood cancer patients are an integral part of patient management, requiring regular ophthalmic evaluations and close collaboration between oncologists and ophthalmologists. Advances in therapy and an increased focus on early symptom recognition are essential for preserving vision and enhancing patient quality of life.

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Section: Secondary Disease Involvementmentioning

confidence: 99%

Ophthalmic Manifestations in Patients with Blood Malignancies

Rossi,

Buizza,

Alessio

et al. 2024

Hematology Reports

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Recognition of Leukemic Retinopathy Using Knowledge of Diabetic Retinopathy

Platas-Campero,

Díaz Hernández,

Altamirano Robles

2024

Lecture Notes in Computer Science

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Highlights of ophthalmological manifestations in newly diagnosed acute leukemia: a correlation with hematological parameters

Laimon,

Sakr,

Atef

et al. 2024

Ann Hematol

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Acute leukemia is a hematological malignancy affecting different organ systems including the eye and orbit through direct infiltration of tissues or secondary to hematological abnormalities. Ophthalmological manifestations in acute leukemia are variable ranging from asymptomatic presentation to serious manifestations that can alter the disease course and treatment. The purpose of this study is to detect the incidence of different ophthalmological manifestations in newly diagnosed acute leukemia patients and to assess the relationship between ocular findings and hematological characteristics and the sequel of these neoplasms. A cross-sectional study with analytical components was conducted on 222 newly diagnosed acute myeloid and acute lymphoblastic leukemia patients who presented at Oncology Center Mansoura University (OCMU) between January 2022 and February 2023. All patients underwent a complete ophthalmic evaluation at Mansoura Ophthalmology Center (MOC). The mean age was 43.45 ± 17.35 years (range, 17–85), and M/F was 137 (61.7%)/85 (38.3%). One-hundred and forty-four (64.9%) had acute myeloid leukemia (AML), and 78 (35.1%) had acute lymphoblastic leukemia (ALL). Ophthalmic manifestations were detected in 96 patients (43.2%). Among them, 4 (1.8%) had poor visual acuity. Retinal hemorrhage (19.8%) and Roth spots (17.1%) were the most common ocular manifestations. Other ophthalmological manifestations observed were orbital involvement (3.2%), ocular motility issues (1.4%), subconjunctival hemorrhage (5.9%), conjunctival chemosis (0.9%),lid swelling (4.1%), lid ecchymosis (3.2%), lagophthalmos (0.5%), lid ptosis (1.8%), retinal venous congestion & tortuosity (4.1%), preretinal hemorrhage (3.2%), vitreous hemorrhage (3.2%), macular affection (2.3%), retinal infiltration (1.8%), exudative retinal detachment (ERD) (1.8%), cotton-wool spots (0.9%), retinal vein occlusion (0.5%), papilledema (2.8%), optic disc infiltration (1.8%), disc pallor (1.8%).AML patients were significantly associated with a higher frequency of ocular affection, retinal hemorrhages, and Roth spots (P 0.028, 0.003, and 0.046, respectively) compared to ALL patients. Retinal hemorrhage was statistically significantly associated with anemia (P 0.021). Ophthalmological manifestations of acute leukemia are heterogeneous; they can be detected at initial presentations or relapse. Some manifestations are asymptomatic, others can affect visual acuity or even alter the disease course. Cooperation between ophthalmologists and haemato-oncologists is crucial for recognizing ocular involvement and disease management.

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Ophthalmic Manifestations of Newly Diagnosed Acute Leukemia Patients in a Tunisian Cohort

Cited by 6 publications

References 21 publications

Ophthalmic Manifestations in Patients with Blood Malignancies

Ophthalmic Manifestations in Patients with Blood Malignancies

Recognition of Leukemic Retinopathy Using Knowledge of Diabetic Retinopathy

Highlights of ophthalmological manifestations in newly diagnosed acute leukemia: a correlation with hematological parameters

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