Open Heart Surgery in a Hemophiliac Patient

Cardiac surgery in patients with haemophilia B: a case report and review of the literature

“…There are several case reports and case series of percutaneous coronary stent insertion and of cardiac surgery in patients with haemophilia A [8][9][10][11][12][13][14] and haemophilia B [11,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Some of the older reports describe perioperative haemostatic strategies that are now outdated, such as plasmapheresis with fresh frozen plasma replacement [17] and reliance on prothrombin complex concentrate [16,18,21].…”

Tetralogy of Fallot and Hemophilia A: Successful Management of Intracardiac Repair

“…There have been some reported cases of patients with factor VIII or factor IX deficiency undergoing open heart surgery for both congenital and acquired cardiac disease with good results. 2 –6 Leggett and colleagues 5 described a successful cardiac operation in a young boy with hemophilia, con-genital heart disease (double-chambered right ventricle with ventricular septal defect), severe factor VIII deficiency, and an acquired high titer of antibodies to factor VIII. A patient with moderately severe hemophilia B who underwent coronary artery bypass grafting with the aid of aprotinin and monoclonal antibody purified factor IX was reported by Palanzo and Sadr.…”

Coagulation Affects Vasculogenesis and Angiogenesis: Does It Affect the Development of the Heart?

“…Recently Jedele et al (37) performed a systematic review of 120 hemophiliac families and found a hemophiliac infant with transposition and the brother of a hemophiliac boy with aortic atresia and hypoplastic left ventricle. In the older literature, successful cardiac operations in hemophiliac patients were reported for atrioventricular septal defect (38), tricuspid atresia (39), and transposition (40).…”