OP0131 Prevalence and Predictors of Small Intestinal Bacterial Overgrowth in Systemic Sclerosis

Abstract

95-raise social awareness and increase public understanding of the debilitating effects of rheumatic diseases. Every year our young association celebrates the 12th October -World Arthritis Day, as a central event in our activities calendar. In 2012, as part of the celebrations, we organized a fashion show. Objectives: To explore and promote opportunities for designing clothes for people with rheumatic and musculoskeletal diseases. Through the visual effect of the fashion show, to bring general public closer to understanding the effects of rheumatic diseases. Methods: The fashion show, themed "Move to Improve", was organized in cooperation with Belgrade Design District and Serbian Media, and was held during the 21 st Maybelline Fashion selection manifestation. The models were volunteers -RMDs sufferers from ORS, who were escorted to the stage by journalists from First Serbian Television Station. The models wore clothes that had been specifically designed to suit people who cannot get dress themselves easily. Results: Young designers did their job very well. They created simple, usable, modern clothes without small buttons, zippers, ribbons. The audience supported very kindly our brave models. The show attracted strong media attention, with reports from this event broadcast by 15 TV and 6 radio stations. Also, 17 printed media and 25 internet portals published stories about the show. Daily newspaper "Blic" organized a mini internet competition for the best fashion show during the whole fashion manifestation and more than 1.3 million visitors voted. With 62% of the votes, "Move to improve" won the prize for the best fashion show during a significant fashion manifestation in Serbia. Conclusions: Our brave volunteers have shown that, in spite of their special needs, people with RMDs can and should follow and create fashion. They were seen and admired by very many people. The "Move to Improve" show is still talked about in Serbia -among ordinary people, health professionals and RMD sufferers ... Background:Elevations of BAFF are observed in patients with SLE. Here we report renal findings from a Phase 2b clinical trial in patients with SLE treated with the subcutaneous BAFF inhibitor, blisibimod. Objectives: To evaluate the effect of 24-week therapy with blisibimod on markers of renal disease in patients with proteinuria or active inflammation. Methods: 547 patients with serologically-active SLE and SELENA SLEDAI ≥6 were randomized to receive placebo or blisibimod. 13.9% of patients had renal involvement at baseline per SELENA-SLEDAI. Proteinuria and inflammation biomarkers were evaluated throughout the study. Results: In a subgroup of subjects with baseline urinary protein equivalent to 1-6g/24hr (n=49), significantly greater reductions in proteinuria were observed with blisibimod compared to placebo from Weeks 8 through 24 (respective mean reductions of 0.73g/24hr (-35.0%) and 0.24g/24hr (-5.1%) at Week 24, p=0.045). Similarly, significantly greater reductions in proteinuria were observed in a subgroup of subjects wi...

Prevalence and associated factors of small intestinal bacterial overgrowth among systemic sclerosis patients

“…Esophageal involvement is most frequently found, occurring in 30%‐96% of SSc cases. Although few studies have been performed on the GI, small intestinal function is not uncommonly affected and is suspected to be compromised in 40% of patients . Impaired motility is thought to affect the small intestine in SSc, likely due to neuronal degradation and collagen deposition .…”

Association between small‐intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries

“…Associations between SIBO and irritable bowel syndrome [3], non-alcoholic fatty liver disease [4], Parkinson's disease [5] and systemic sclerosis [6] have been suggested in previous studies.…”

Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis

“…In the group of patients without any predisposing conditions, we included subjects in which factors predisposing to SIBO such as abdominal surgery, celiac disease, connective tissue disorders, and others as listed in. [4][5][6][7][8][9][10] In 6 studies the sub-category of patients without any predisposing conditions was considered. 21,22,24,28,30,32 Three hundred and forty patients were enrolled in this subgroup, which was constituted mainly by healthy controls, elderly patients with diarrhea, and IBS patients.…”

“…Several processes predispose to bacterial overgrowth such as anatomical/structural changes of the small intestine (previous gastrointestinal surgery), motility disorders (such as gastroparesis), metabolic disorders (gastric hypochlorhydria and diabetes), organ system dysfunctions (cirrhosis, renal failure, chronic pancreatitis, Crohn's disease, and celiac disease), medications (prolonged use of proton pump inhibitors and antibiotics), and irritable bowel syndrome (IBS). [4][5][6][7][8][9][10] The most common symptoms are diarrhea, abdominal pain and bloating, but weight loss, malnutrition, and deficiency of vitamins (B12, D, A, and E) and minerals (iron and calcium) are possible. 1 The flora of SIBO patients is mainly characterized by the prevalence of coliform bacteria and anaerobes, which cause fermentation of carbohydrates, compete with vitamin and micronutrient absorption and engender microscopic mucosal inflammation, thus leading to the above described symptoms.…”