Oocyte retrieval difficulties in women with ovarian endometriomas

Benaglia, Laura; Busnelli, Andrea; Biancardi, Rossella; Vegetti, Walter; Reschini, Marco; Vercellini, Paolo; Somigliana, Edgardo

doi:10.1016/j.rbmo.2018.03.020

Cited by 41 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in accordance with the available literature and is explained by the lower ovarian reserve in these patients [7][8][9][10][11][12]56]. Another added factor that could contribute to the lower oocyte yield is the difficult access to the follicles during retrievals in the presence of large endometriomas [57]. The significantly lower number of embryos and top-quality embryos available is the direct consequence of the lower oocyte yield.…”

Section: Discussionsupporting

confidence: 87%

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

View full text Add to dashboard Cite

Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.

show abstract

Section: Discussionsupporting

confidence: 87%

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…In most reproductive institutions, follicles with diameter ≥ 10 mm were aspirated during oocyte collection procedures. Thus the oocyte retrieval rate was usually determined as the ratio of the number of oocytes collected to the number of follicles ≥ 10 mm [15,16]. However, several studies debated that reduced maturity and fertilization ability for oocytes collected from small follicles and aspiration of those follicles were not recommended [17,18].…”

Section: Discussionmentioning

confidence: 99%

Defining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive CenterDefining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive Center

Cao

You

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: The objective of this study was to determine the novice trainee’s learning curve for oocytes retrieval procedure through assessment of oocytes retrieval efficiency, operative time and other operative characteristics. Methods: This retrospective cohort study included 200 consecutive patients undergoing transvaginal ultrasound guided oocytes retrieval procedure. Those patients underwent oocyte retrieval procedure by a single operator and one experienced supervisor. Their clinical data, including demographic data, ovarian stimulation cycle information, surgical procedure, and laboratory data were collected over 3 months. CUSUM analyses based on the operative time were performed to determine the learning curve. Results: The mean operative time was 10.10 min. Based on the CUSUM plot of operative time, the learning curve can be divided into three separated phases, phase 1 (case 1 to case 49) was learning phase, phase 2 (case 50 to case 130) was acquisition phase, and phase 3 (case 131 to case 200) was proficiency phase. The operative time was significantly shortened from phase 1 to phase 3 (phase 1, 13.37 ± 4.83min; phase 2, 10.21 ± 3.30 min; phase 3, 7.67 ± 3.24 min, P < 0.001). The oocyte retrieval efficiency was also notably improved from phase 1 to phase 3 (78.2% to 100% based on method 1 to determine oocyte retrieval efficiency, and 104.2% to 121.1% based on method 2 to determine oocyte retrieval efficiency). The retrieved oocytes number, the fertilization rate, clinical pregnancy rate among the three phases showed no significant differences. No patients had severe adverse events. As determined by multiple linear regression, learning phase is the only independent predictor of oocyte retrieval efficiency. Conclusion: Trainees practice transvaginal ultrasound guided oocytes retrieval are expected to achieve a stabilized procedure over consecutive training cases, with acquisition of the skills at 49 cases, and proficiency at 130 cases. Cumulative operative experience can improve the operative time and oocytes retrieval efficiency, but showed minimal influence on retrieved oocytes number and reproductive outcomes.

show abstract

“…Women undergoing IVF followed standardized protocols that are reported in detail elsewhere (12)(13)(14). According to the policy of our Center and in line with local legislation, all women obtaining a pregnancy with IVF were actively followed up 9-12 months after the successful cycle.…”

Section: Methodsmentioning

confidence: 99%

Endometriosis and spontaneous hemoperitoneum in pregnancy: evaluation of the magnitude of the risk in women becoming pregnant via in vitro fertilization

Benaglia

Reschini

Vecchia

et al. 2021

Fertility and Sterility

Self Cite

View full text Add to dashboard Cite

Objective: To estimate the frequency of Spontaneous Hemoperitoneum in Pregnancy (SHiP) in women with endometriosis achieving pregnancy with IVF. Design: Retrospective case series of women with endometriosis obtaining pregnancy with IVF Setting: A referral academic ART center Patients/Animals: Women with a history of surgery for endometriosis as well as those with ovarian endometriomas or deep endometriotic nodules at the basal transvaginal ultrasound performed prior to initiate the IVF cycle could be included. Women who had a miscarriage before 12 weeks' gestation were excluded. Interventions: Information regarding basal characteristics, IVF cycle and pregnancy outcome was obtained from patients' charts. A binomial distribution model was used to determine the 95%CI of the proportion of SHiP. Main Outcome Measure: Rate of SHiP Results: Overall, 362 pregnancies were included: 238 (66%) had a history of previous surgery for endometriosis and 231 (64%) had endometriosis at ultrasound (107 corresponding to 30% had both). Pregnancies were obtained after fresh and frozen cycles in 244 (67%) and 118 (33%) women, respectively. One case of SHiP was recorded, corresponding to a rate of 0.3% (95%CI: <0.1-1.5%). Conclusions: SHiP is uncommon in the general population of women with endometriosis undergoing IVF. Future studies should better identify risk factors for SHiP in order to disentangle subgroups of women at higher risk.

show abstract

Oocyte retrieval difficulties in women with ovarian endometriomas

Abstract: Oocyte retrieval in women with ovarian endometriomas is more problematic but the magnitude of these increased difficulties is modest.

Cited by 41 publications

References 21 publications

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Defining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive CenterDefining the Learning Curve is Necessary to Improve Oocyte Retrieval Skills: Lessons from A Single High-Volume Reproductive Center

Endometriosis and spontaneous hemoperitoneum in pregnancy: evaluation of the magnitude of the risk in women becoming pregnant via in vitro fertilization

Contact Info

Product

Resources

About