Onychomadesis associated with pemphigus vulgaris

Nail involvement in pemphigus vulgaris

“…In the present study we demonstrated that nail changes in patients with PV were much more frequent than is currently documented 4–13 . Thirty of 64 (47%) patients with PV in our study had nail changes during the course of their disease, of which 14 (22%) were due to PV affecting the nail unit.…”

“…There is little information on nail changes in patients with PV. Pardo‐Castello 3 and Parameswara and Chinnappiah 4 suggested that periungual bullae might be responsible for dystrophic changes of the nail and interfere with the function of the matrix. According to Baumal and Robinson 5 and Fulton et al ., 6 the primary defect affects the nail bed.…”

Unusual presentation of pemphigus vulgaris

“…Nail and eye involvement in pemphigus vulgaris are unusual and there are only a few reports in the literature [1][2][3][4][5]. In most cases, nail lesions are secondary to the presence of bullae on the distal portion of the finger.…”

Nail findings in pemphigus vulgaris

“…Nail involvement in PV is thought to be relatively uncommon, although a recent study shows it may be present in up to 38% of patients with PV 3 . The most common nail manifestations found in PV are chronic paronychia and onychomadesis 4–9 . Other reported changes include nail‐plate discoloration, trachyonychia, onychorrhexis, onycholysis, Beau's lines, subungual hemorrhage and subungual hyperkeratosis 3,4,6–13 .…”

“…Other reported changes include nail‐plate discoloration, trachyonychia, onychorrhexis, onycholysis, Beau's lines, subungual hemorrhage and subungual hyperkeratosis 3,4,6–13 . Such lesions can occur as the initial presentation of PV, 5,6,8,12,13 during a flare of the disease, 7,11,13 or between disease exacerbations 6,910,13 . Fingernails are believed to be affected more commonly than toenails.…”