Ontogenesis of Lateralization

Güntürkün, Onur; Ocklenburg, Sebastian

doi:10.1016/j.neuron.2017.02.045

Cited by 184 publications

(153 citation statements)

References 172 publications

(193 reference statements)

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“…Hemispheric asymmetries are a major principle of brain organization in many vertebrate (Ocklenburg et al, 2013d; Ströckens et al, 2013; Güntürkün and Ocklenburg, 2017) and invertebrate species (Frasnelli, 2013). In humans, handedness and language lateralization are related to some extent.…”

Section: Introductionmentioning

confidence: 99%

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

et al. 2017

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Handedness and language lateralization are partially determined by genetic influences. It has been estimated that at least 40 (and potentially more) possibly interacting genes may influence the ontogenesis of hemispheric asymmetries. Recently, it has been suggested that analyzing the genetics of hemispheric asymmetries on the level of gene ontology sets, rather than at the level of individual genes, might be more informative for understanding the underlying functional cascades. Here, we performed gene ontology, pathway and disease association analyses on genes that have previously been associated with handedness and language lateralization. Significant gene ontology sets for handedness were anatomical structure development, pattern specification (especially asymmetry formation) and biological regulation. Pathway analysis highlighted the importance of the TGF-beta signaling pathway for handedness ontogenesis. Significant gene ontology sets for language lateralization were responses to different stimuli, nervous system development, transport, signaling, and biological regulation. Despite the fact that some authors assume that handedness and language lateralization share a common ontogenetic basis, gene ontology sets barely overlap between phenotypes. Compared to genes involved in handedness, which mostly contribute to structural development, genes involved in language lateralization rather contribute to activity-dependent cognitive processes. Disease association analysis revealed associations of genes involved in handedness with diseases affecting the whole body, while genes involved in language lateralization were specifically engaged in mental and neurological diseases. These findings further support the idea that handedness and language lateralization are ontogenetically independent, complex phenotypes.

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Section: Introductionmentioning

confidence: 99%

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

et al. 2017

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“…Asymmetries in avian species have been found in visual processing from sensory input to motor output, admittedly largely in domestic chickens [7,8] and pigeons [9]. Lateralized foot use has been shown in pigeons [10,11], the New Zealand kākā [12], some songbirds (sittellas and crested shrike-tits [13]), Japanese jungle crow [14] and also in cockatoos and some parrots [7,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Audition and Hemispheric Specialization in Songbirds and New Evidence from Australian Magpies

Kaplan

2017

Symmetry

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Abstract:The neural processes of bird song and song development have become a model for research relevant to human acquisition of language, but in fact, very few avian species have been tested for lateralization of the way in which their audio-vocal system is engaged in perception, motor output and cognition. Moreover, the models that have been developed have been premised on birds with strong vocal dimorphism, with a tendency to species with complex social and/or monomorphic song systems. The Australian magpie (Gymnorhina tibicen) is an excellent model for the study of communication and vocal plasticity with a sophisticated behavioural repertoire, and some of its expression depends on functional asymmetry. This paper summarizes research on vocal mechanisms and presents field-work results of behavior in the Australian magpie. For the first time, evidence is presented and discussed about lateralized behaviour in one of the foremost songbirds in response to specific and specialized auditory and visual experiences under natural conditions. It presents the first example of auditory lateralization evident in the birds' natural environment by describing an extractive foraging event that has not been described previously in any avian species. It also discusses the first example of auditory behavioral asymmetry in a songbird tested under natural conditions.

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“…Directional movements of myocardial cells are involved in the rotation of the zebrafish cardiac cone (Baker et al, 2008;Rohr et al, 2008;Smith et al, 2008), whereas rotation of the fly hindgut is associated with the chiral activity of the atypical myosin Myo1d, propagated by Planar Cell Polarity (González-Morales et al, 2015). Asymmetries preceding that of Nodal are evident in the brain, involving Fgf, Notch or Wnt/β-catenin signalling (see Güntürkün and Ocklenburg, 2017), or in the frog embryo, involving ion channels or cytoskeletal rearrangements (Pai et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop

Desgrange

Garrec

Bernheim

et al. 2019

Preprint

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The secreted factor Nodal has been shown to be a major left determinant. Although it is associated with severe congenital heart defects, its role in heart morphogenesis has remained poorly understood. Here, we report that Nodal is transiently active in precursors of the mouse heart tube poles, before the morphological changes of heart looping. In conditional mutants, we show that Nodal is not required to initiate asymmetric morphogenesis. We provide evidence of a heart-specific random generator of asymmetry that is independent of Nodal. Using 3D quantifications and simulations, we demonstrate that Nodal functions as a bias of this mechanism: it is required to amplify and coordinate opposed left-right asymmetries at the heart tube poles, thus generating a robust helical shape. We identify downstream effectors of Nodal signalling, regulating asymmetries in cell proliferation, cell differentiation and extra-cellular matrix composition. Our work provides novel insight into how Nodal regulates asymmetric organogenesis.

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Ontogenesis of Lateralization

Cited by 184 publications

References 172 publications

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

Audition and Hemispheric Specialization in Songbirds and New Evidence from Australian Magpies

Transient Nodal signalling in left precursors coordinates opposed asymmetries shaping the heart loop

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