Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity

Elsheikh, Elzafir; Uzunel, Mehmet; He, Zhong; Holgersson, Jan; Nowak, G.; Sumitran–Holgersson, Suchitra

doi:10.1182/blood-2005-04-1407

Cited by 106 publications

(80 citation statements)

References 33 publications

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“…This finding is consistent with results from several laboratories that have reported circulating cells with myeloid features contributing to human angiogenesis (8)(9)(10)(11). Importantly, we have also shown that donor-derived endothelial cells differentiate from myeloid progenitors and are not products of cell fusion.…”

Section: Discussionsupporting

confidence: 82%

“…Human circulating and bone marrow-derived endothelial progenitor activity has previously been reported in transplant recipients (6,7). However, functional studies of human endothelial progenitors (8)(9)(10)(11) have mainly relied on in vitro assays. Although expression of the myelomonocytic marker CD14 appears to be a common feature of these circulating progenitors, it has been challenging to determine both the phenotype and origin of these cells.…”

mentioning

confidence: 99%

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Myeloid lineage progenitors give rise to vascular endothelium

Bailey

Willenbring

Jiang

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

181

166

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Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 99%

Myeloid lineage progenitors give rise to vascular endothelium

Bailey

Willenbring

Jiang

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

181

166

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“…Most importantly, previous studies showed that CD14 + KDR + cells exhibit the potential to differentiate into cells with endothelial characteristics both in vitro and in vivo (Nowak et al 2004;Elsheikh et al 2005). Our study showed CD14 + KDR + cells constituting approximately 2.02%±1.41% of the total population of monocytes in the blood, which is very closely to the observation of Elsheikh et al (2005) (2%±0.5%). The number of CD14 + KDR + cells in the blood was not significantly different in controls compared with patients with stable CAD or ACS.…”

Section: Determinants Of Circulating Cd14 + -Epcs Levelssupporting

confidence: 86%

Level of CD14+-endothelial progenitor cells is not associated with coronary artery disease or cardiovascular risk factors

Qiang

Jiang

et al. 2008

AGE

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There is evidence for two subpopulations among circulating endothelial progenitor cells (EPCs), i.e., CD34 + -EPCs and CD14 + -EPCs. Prior studies on the relationship between the level of EPCs and coronary artery disease (CAD), either did not distinguish between the two types of EPCs or studied only CD34 + -EPCs. We therefore investigated whether the number of circulating CD14 + -EPCs correlates with either CAD and/or cardiovascular risk factors. Circulating CD14 + -EPCs-as defined by the surface markers CD14 + KDR + -were analyzed by flow cytometry in 100 individuals [34 control subjects, 41 patients with stable CAD and 25 patients with acute coronary syndromes (ACS)]. The level of circulating CD14 + -EPCs was not significantly different in patients with normal coronary arteries compared to those with stable CAD or ACS. Neither was there any association between the severity of CAD or risk factors and the number of circulating CD14 + -EPCs. Thus, the number of circulating CD14 + -EPCs was not significantly correlated either with the severity of coronary disease or with cardiovascular risk factors.

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“…5,13 Also accumulating evidence supports the hypothesis that a population of circulating CD14 þ monocytes can be a source of EPCs. 14,15 Moreover, Krankel et al 16 showed that type B2 receptor for bradykinin is expressed on EPCs. The presence of type B2 receptor is consistent with the chemoattractant effects of bradykinin, which in turn is guided by the migration of proangiogenic progenitor cells.…”

Section: Endothelial Progenitor Cellsmentioning

confidence: 99%

Mobilization of stem and progenitor cells in cardiovascular diseases

et al. 2011

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Circulating bone marrow (BM)-derived stem and progenitor cells (SPCs) participate in turnover of vascular endothelium and myocardial repair after acute coronary syndromes. Acute myocardial infarction (MI) produces a generalized inflammatory reaction, including mobilization of SPCs, increased local production of chemoattractants in the ischemic myocardium, as well as neural and humoral signals activating the SPC egress from the BM. Several types of circulating BM cells were identified in the peripheral blood, including hematopoietic stem cells, endothelial progenitor cells, mesenchymal stromal cells, circulating angiogenic cells and pluripotent very small embryonic-like cells; however, the contribution of circulating cells to the myocardial and endothelial repair is still unknown. The number and function of these cells is impaired in patients with diabetes and other cardiovascular risk factors, but can be improved by physical exercise and use of statins. The mobilization of SPCs in acute coronary syndromes and stable coronary artery disease seems to predict the clinical outcomes in selected groups of patients. Interpretation of the findings has to incorporate other factors that modulate the process of mobilization, such as coexisting diseases, age and medications. This review discusses the mobilization of SPCs in acute ischemia (MI, stroke), as well as in stable cardiovascular disease, and highlights the possibility of using the SPC as a marker of cardiovascular risk.

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Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity

Cited by 106 publications

References 33 publications

Myeloid lineage progenitors give rise to vascular endothelium

Myeloid lineage progenitors give rise to vascular endothelium

Level of CD14+-endothelial progenitor cells is not associated with coronary artery disease or cardiovascular risk factors

Mobilization of stem and progenitor cells in cardiovascular diseases

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