2001
DOI: 10.1055/s-2001-14294 View full text |Buy / Rent full text
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Abstract: The intravascular application of NIR spectroscopy could be a reliable tool in detection and follow-up of acute myocardial ischemia and infarction.

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“…The application of optical spectroscopy to heart disease is still very limited and only a few in vivo studies have been reported. Many of these studies utilized reflectance spectroscopy to characterize the hemodynamic state of the heart by quantification of the tissue oxygenation and hemoglobin and myoglobin concentrations [15][16][17][18]. Other studies used steady-state autofluorescence intensity or emission spectroscopy to report cardiac tissue viability and metabolic state [7,19,20].…”
Section: Introductionmentioning
“…In this study, we report a novel approach to cardiac investigation by applying TRFS to a rat 16 week post myocardial infarction heart failure (MI-HF) model that was previously well characterized in our laboratory [36][37][38][39][40]. The diagnosis of heart failure traditionally rested upon demonstration of impaired systolic function of the ventricle [8], although it is clear that heart failure can occur in the absence of reduced systolic function when reported as ejection fraction.…”
Section: Introductionmentioning
“…2). 9,10 Intraoperatively, measurements were carried out before surgery (baseline), after completing the anastomosis with left internal thoracic artery to the left anterior descending artery (LAD), and after complete revascularization with central anastomoses. The signal acquisition time was fixed to 5 minutes, covering the mean values of 5 subsequent analyses of 1 minute each.…”
Section: Nir Spectroscopic Settingmentioning
“…The application was evaluated in acute myocardial ischemia-reperfusion experiments in animals by using the coronary sinus access. 9,10 For online myocardial ischemia monitoring, intravascular NIR spectroscopy has not yet been evaluated in humans.…”
Section: Introductionmentioning
“…This technique is a hybrid of imaging and NIR spectroscopy, which has been widely exploited to monitor blood oxygen saturation. [3][4][5] Both NIR spectroscopy and spectroscopic imaging make use of the distinct absorptivity spectra of deoxygenated (deoxy-Hb) and oxygenated hemoglobin (oxy-Hb) as well as the relatively deep tissue penetration of NIR light (Ͼ5 mm) relative to visible light (Ͻ5 mm) to measure tissue oxygenation in vivo.…”
Section: Introductionmentioning