Abstract:Recent advancements in mass spectrometry (MS) now enable
all levels
of protein structures to be characterized, including primary protein
sequence, post-translational modifications, and three-dimensional
protein conformations. However, protein conformational studies by
MS require the use of many separate techniques that are performed
independently of each other. Herein, we described a contained-electrospray
(ES) experiment that has potential to integrate peptide/protein cross-linking
with the general MS workflo… Show more
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