One‐year change in radiographic joint space width in patients with unilateral joint space narrowing: Data from the osteoarthritis initiative

Abstract

Objective. To examine the rate of joint space width (JSW) loss in both knees of patients with unilateral medial joint space narrowing (JSN) at baseline. Methods. Cases were selected from a pool of 2,678 subjects enrolled in the Osteoarthritis Initiative cohort. Inclusion criteria for the present study were unilateral medial JSN, bilateral frequent knee pain, and body mass index (BMI) >25 kg/m 2 . Baseline and 1-year fixed flexion radiographs of both knees were read (blinded to time point) using an automated algorithm for minimum JSW and JSW at 4 fixed locations in the medial compartment. Results. Sixty-seven participants met the inclusion criteria: 43 women and 24 men, with mean ؎ SD age 60 ؎ 9 years and mean ؎ SD BMI 31 ؎ 4 kg/m 2 . Thirty-seven subjects (55%) had >1 definite tibiofemoral osteophyte. The average progression in no-JSN knees was comparable with that in JSN knees (approximately ؊0.2 mm/year). However, JSW change was more variable in no-JSN knees, resulting in standardized response means (SRMs; the mean/SD) of approximately ؊0.24 in no-JSN knees versus approximately ؊0.41 in JSN knees on average at the 4 fixed locations, and SRMs of ؊0.24 and ؊0.35, respectively, for minimum JSW. Young age and high BMI were associated with increased progression, especially in JSN knees. Conclusion. JSN and no-JSN knees progressed at a comparable rate, but a wider distribution of JSW change in no-JSN knees resulted in a poorer sensitivity to change in these knees.

Quantitative Radiographic Progression of Joint Space Narrowing in Medial and Lateral Compartment Knee Osteoarthritis After Intraarticular Platelet-Rich Plasma Injection

“…At a median radiographic follow-up of 11.5 months in 20 knees, we found a median change in JSW of −0.1 mm for the predominant KOA compartment. This is slightly less than the rate of narrowing reported by Emrani et al [ 30 ] and Benichou et al [ 31 ] in untreated KOA, but our sample size is too small to confidently attribute the difference to PRP. Although further stratification of JSW change by KL grade would be ideal, this was not possible due to the small number of knees in our study.…”

Three‐dimensional mapping of the joint space for the diagnosis of knee osteoarthritis based on high resolution computed tomography: Comparison with radiographic, outerbridge, and meniscal classifications

“…33 On radiographs the most used parameter extracted was JS_min with an annual rate of progression of $0.2 mm for OA patients. 34 In the present study, for this parameter, the difference between the two operators was about 10 times less than the supposed annual variation. The JS_asym was found constantly correlated with the cartilage thickness measured at three different sites and consequently presents a special interest.…”

“…On radiographs the most used parameter extracted was JS_min with an annual rate of progression of ∼0.2 mm for OA patients 34. In the present study, for this parameter, the difference between the two operators was about 10 times less than the supposed annual variation.…”

Radiographic Incidence of Knee Osteoarthritis After Isolated ACL Reconstruction Versus Combined ACL and ALL Reconstruction: A Prospective Matched Study From the SANTI Study Group

“…Quantitative methods that measure joint space provide an approximation of the articular cartilage thickness narrowing 1 and have been shown to be comparable with MRI cartilage thickness assessment. 2,17,41 In the current study, no differences in degenerative changes were found when using commonly reported grading systems, such as Kellgren-Lawrence 32 or IKDC. All of the aforementioned systems were designed for use in patients who are typically older than those receiving an ACLR and who seek to quantify the degree of OA once it is established.…”