One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives

Abstract

The title compounds, substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-ones were obtained by reacting 3-aryl-1-(3-coumarinyl)propen-1-ones with 2-napthol catalyzed by DBU (1,8-diazabicyclo[5,4,0]undec-7-ene) and concentrated H2SO4 in ample yields. Their structures were characterized by IR, 1 H NMR, 13 C NMR, mass spectral and elemental analysis. All the synthesized compounds have been evaluated for their in-vitro antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and antifungal activity against Aspergillus Niger and Candida albicans by using serial broth dilution method. Among those compounds 3 band 3c exhibits prominent results.

Advancements in the Preparation of 4H‐Chromenes: An Overview

“…reported a similar reaction by utilizing 3‐aryl‐1‐(3‐coumarinyl)propen‐1‐ones 356 and 2‐naphol 111 a as substrates to synthesize 4‐aryl‐2‐coumarinyl‐4 H ‐chromenes 357 in 58–78% yields (Scheme 86). [82b] The reaction proceeded smoothly by using DBU as catalyst in CH 2 Cl 2 at room temperature for 12 hours followed by further stirring the reaction mixture with the aid of a drop of concentrated H 2 SO 4 for 3 hours at room temperature.…”