One-pot synthesis of a chitosan-based hydrogel as a potential device for magnetic biomaterial

Paulino, Alexandre Tadeu; Guilherme, Marcos R.; Almeida, Elisangela A.M.S. de; Pereira, Antonio G.B.; Muniz, Edvani C.; Tambourgi, Elias Basile

doi:10.1016/j.jmmm.2009.03.078

Cited by 42 publications

(23 citation statements)

References 19 publications

(26 reference statements)

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“…The band that absorbed at 1642 cm -1 was a result of the predominance of the amino group (N-H). Similar results were found by Paulino et al (2009) when they analyzed the infrared spectrum of chitosan.…”

Section: Ftirsupporting

confidence: 84%

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Reinas¹,

Hoscheid²,

Outuki³

et al. 2014

Braz. J. Pharm. Sci.

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An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescens Benth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/ chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule morphology. The obtained formulations were slightly yellow, odorless, and had a pleasant taste. The average diameters of the microcapsules were 0.4679 µm (F2-MC), 0.5885 µm (F3-MC), and 0.9033 µm (F1-MC). The best formulation was F3-MC, with FHPp microencapsulation efficiency of 61.01 ± 2.00% and an in vitro release profile of 75.88 ± 0.45%; the content of vouacapans 3-4 was 99.49 ± 2.80%. The best model to describe the release kinetics for F1-MC and F3-MC was that proposed by Higuchi; however, F2-MC release displayed firstorder kinetics; the release mechanism was of the supercase II type for all formulations.Uniterms: Pterodon pubescens Benth./pharmacognosy. Sucupira. Microcapsules/preparation. Vouacapans. Alginate. Chitosan. Coacervation method. Natural polymers. Natural products.Uma fração oleaginosa obtida do extrato etanólico de frutos de Pterodon pubescens Benth (FHPp) foi microencapsulada em um sistema polimérico. Estes sistemas foram desenvolvidos utilizando o método de coacervação complexa, constituído de alginato/quitosana massa molecular média (F1-MC), alginato/ quitosana com desacetilação superior a 75% (F2-MC) e alginato/quitosana de massa molecular baixa (F3-MC). Estes sistemas desenvolvidos têm o potencial tanto de mascarar o sabor do extrato, quanto de protegê-lo de possível degradação química. A influência dos parâmetros de formulação e processo foram determinadas por caracterização química, determinação da eficiência de microencapsulação da fração oleaginosa e por avaliação morfológica da microcápsula. As formulações mostraram-se ligeiramente amareladas, inodoras e com sabor agradável. Os diâmetros médios das microcápsulas foram de 0,4679 µm (F2-MC), 0,5885 µm (F3-MC) e 0,9033 µm (F1-MC). A melhor formulação foi F3-MC, considerando-se que apresentou eficiência de encapsulação de 61,01 ± 2,00%, e perfil de liberação in vitro de 75,88 ± 0,45%; o conteúdo dos vouacapanos 3-4 foi 99,49 ± 2,80%. O melhor modelo para descrever a cinética de liberação foi o modelo proposto por Higuchi para F1-MC e F3-MC, entretanto, para F2-MC foi o modelo de primeira ordem, e o mecanismo de liberação foi do tipo super caso II para todas as formulações.Unitermos: Pterodon pubescens Benth./farmacognosia. Sucupira. Microcápsulas/preparação. Vouacapanos. Alginato. Quitosana. ...

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Section: Ftirsupporting

confidence: 84%

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Reinas¹,

Hoscheid²,

Outuki³

et al. 2014

Braz. J. Pharm. Sci.

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“…The following materials were used: chitosan (CS) extracted from silkworm chrysalides with a 90% degree of deacetylation and a molar mass of 1.0 × 10 6 daltons [27], acetic acid (Ac, Merck), acrylic acid (AAc, Merck), glycidyl methacrylate (GMA, Across Organics), methylenebisacrylamide (MBA), hydrochloric acid (HCl, Merck), ammonium persulfate (APS, Aldrich), gum arabic (GA, Company -Sudan), sodium hydroxide (NaOH, Nuclear), acrylamide (AAm, Aldrich), potassium acrylate (KAAc, Aldrich), maltodextrin (MD, Aldrich), ethanol (TEDIA), magnetite nanoparticles (Fe 3 O 4 ) purchased from Fisher Scientific and characterized elsewhere [25]. All experiments were performed using Milli-Q TM water.…”

Section: Methodsmentioning

confidence: 99%

“…The resulting hydrogel was dried in an oven at 50 • C for 12 h prior to characterization and application. The detailed synthesis and characterization of the CS-based hydrogel with and without magnetic properties is described elsewhere [25].…”

Section: Synthesis Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…Some polysaccharide-based hydrogels have been developed for the removal of dyes from water and industrial effluents [23] as well as the removal of Cu 2+ and Pb 2+ from natural water [24]. Hydrogels with magnetic properties may also be used as adsorbent material [25,26]. For instance, a chitosan-based magnetic hydrogel was prepared for the removal of textile dyes from industrial effluent [26].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, a chitosan-based magnetic hydrogel was prepared for the removal of textile dyes from industrial effluent [26]. From a technological standpoint, the greatest advantages of using polysaccharide-based magnetic hydrogels as adsorbent material for heavy metals are the simplicity of the synthesis, the speed of application, the non-toxicity of the final material, precision and ease of application [25].…”

Section: Introductionmentioning

confidence: 99%

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Efficiency of hydrogels based on natural polysaccharides in the removal of Cd2+ ions from aqueous solutions

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Synthesis and characterization of chitosan‐graft‐poly(acrylic acid)/nontronite hydrogel composites based on a design of experiments

Rodrigues

Pereira

Fajardo

et al. 2012

J of Applied Polymer Sci

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A 2 4-1 fractional factorial design was used to evaluate the effect of some parameters, such as the acrylic acid (AA)/chitosan (CTS) molar ratio, crosslinker concentration, initiator concentration, and filler concentration, in the swelling capacity of superabsorbent hydrogel composites based on CTS-graft-poly(acrylic acid) and nontronite clay. The data from wide-angle X-ray scattering and Fourier transform infrared spectroscopy confirmed the syntheses of the hydrogel composites. Main and interaction effects were analyzed by analysis of variance, F tests, and p values. We found that the AA/CTS and crosslinker were the most influential effects in the evaluated response. The proposed statistical model presented a high coefficient of determination (R 2 ¼ 0.985). In addition to the swelling kinetics, the effects of pH and salt for the both compositions (with and without filler), which presented the best water uptake, were evaluated. Both hydrogels showed responsive behavior in relation to the pH and the salt solution, presenting good potential for application as devices in the controlled release of solutes.

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One-pot synthesis of a chitosan-based hydrogel as a potential device for magnetic biomaterial

Cited by 42 publications

References 19 publications

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Efficiency of hydrogels based on natural polysaccharides in the removal of Cd2+ ions from aqueous solutions

Synthesis and characterization of chitosan‐graft‐poly(acrylic acid)/nontronite hydrogel composites based on a design of experiments

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