One-pot green synthesis of biocompatible arginine-stabilized magnetic nanoparticles

Abstract

A green one-step approach has been developed for the synthesis of amino-functionalized magnetite nanoparticles. The synthesis was accomplished by simply mixing FeCl2 with arginine under ambient conditions. It was found that the Fe2+/arginine molar ratio, reaction duration and temperature greatly influence the size, morphology and composition of magnetic nanoparticles. The arginine-stabilized magnetic nanoparticles were characterized by transmission electron microscopy, x-ray diffraction, x-ray photoelectron spectroscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy techniques. The results show that the prepared nanoparticles are spherically shaped with a nearly uniform size distribution and pure magnetite phase. The presence of arginine on the magnetic nanoparticle surface has been confirmed and the amount of surface arginine varies with the Fe2+/arginine molar ratio. The surface amine densities are calculated to be 5.60 and 7.84 micromol mg(-1) for magnetic nanoparticles prepared at 1:1 and 1:2 Fe2+/arginine molar ratio, respectively. The as-synthesized nanoparticles show superparamagnetic behavior at room temperature and good solubility in water. In addition, using a similar synthesis procedure, we have been able to synthesize superparamagnetic manganese and cobalt ferrite nanoparticles.

Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)

“…26 To alleviate this impact, the reaction time of synthesis in the presence of amino acids has been increased to 1.5 h in contrast to 1 h in the absence of amino acids. More time is therefore provided for the growth of nanocrystals and prepared amino-acid coated nanoparticles will be more similar to naked nanoparticles in size.…”

“…[24][25][26] The schematic possible structures for amino-acid coating on Fe 3 O 4 nanoparticles have previously been suggested based on attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) (Scheme 1).…”

“…Particle size distribution and mean particle size were determined by measuring diameters of one hundred nanoparticles randomly selected on the TEM images. 26,34 The crystallinity of synthesised Fe 3 O 4 nanoparticles was studied with an x-ray diffractometer (Siemens D5000).…”

Green synthesis and characterisation of L-Serine capped magnetite nanoparticles for removal of Rhodamine B from contaminated water

“…Nanoparticles due to their high surface to volume ratio, coordinative unsaturated surface species undergo either defects or chemical interaction (Figure 7). Carboxylate ions have two possible interaction modalities to Fe 3C /Fe 2C either uni-or bi-dentate as shown in Figure 7(a,b); however, FTIR analysis was ascribed the bi-dentate [24]. The amino group of L-Ser (Figure 8(c) …”

Coating of L-Arginine Modified Silica on Magnetite through Two Different Sol-Gel Routes

“…The addition of basic organic compounds such as L-arginine stabilized magnetite nanoparticles [15][16]. To attach organic functional groups on the magnetite coated silica, a coupling agent is needed.…”