Oncological outcomes of salvage radical prostatectomy for recurrent prostate cancer in the contemporary era: A multicenter retrospective study

Marra, Giancarlo; Karnes, R. Jeffrey; Calleris, Giorgio; Oderda, Marco; Alessio, P.; Palazzetti, Anna; Battaglia, Antonino; Pisano, Francesca; Munegato, Stefania; Muñoz, Fernándo; Filippini, Claudia; Ricardi, Umberto; Linares, Estefanía; Sánchez-Salas, Rafael; Goonewardene, Sanchia S.; Dasgupta, Prokar; Challacombe, Ben; Popert, Rick; Cahill, Declan; Gillatt, David; Persad, Raj; Palou, Juan; Joniau, Steven; Smelzo, Salvatore; Piéchaud, Thierry; Taille, Alexandre de la; Rouprêt, Morgan; Albisinni, Simone; Velthoven, Roland Van; Morlacco, Alessandro; Vp, Sharma; Gandaglia, Giorgio; Mottrie, Alexander; Smith, Joseph A.; Joshi, Shreyas; Fiscus, Gabriel; Berger, André; Aron, Monish; Abreu, Andre; Gill, Inderbir S.; Poel, Henk van der; Tilki, Derya; Murphy, Declan; Lawrentschuk, Nathan; Davis, John W.; Gontero, Paolo

doi:10.1016/j.urolonc.2020.11.002

Cited by 27 publications

(22 citation statements)

References 23 publications

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“…A meta-analysis from 2012 suggest that 18–53% of patients will have a measurable PSA within 5 years of surgery where [ 13 ]. These data are further supported by more contemporary studies with a recent multi-center study on sRARP suggesting a 5-year biochemical recurrence-free survival of 56.7% [ 14 ].…”

Section: Discussionsupporting

confidence: 62%

Introduction of salvage prostatectomy in Denmark: the initial experience

Mortensen

Poulsen

Ahlgren³

et al. 2022

BMC Res Notes

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Objective To introduce salvage prostatectomy in Denmark. Prior to this, no national curative treatment for recurrent prostate cancer following radiation therapy existed in Denmark. This pilot study represent our initial experiences and the feasibility of performing salvage robot-assisted radical prostatectomy for true local, high-risk recurrence after initial therapy with external beam radiation for high-risk prostate cancer. Results Five patients underwent sRARP between April 2020 and July 2021. All patients were discharged within 48 h and no major complications were observed within 3 months. All patients had unmeasurable PSA (< 0.1 ng/ml) at follow-up 6 months after surgery. One patient with longer follow-up than 6 months experienced biochemical recurrence. At 3-months follow-up all patients reported considerable incontinence, at 6-month follow-up, pad usage decreased to 1 or 2 pads daily. Based on our initial results, the idea to introduce sRARP as a nationwide option remains and further patients will be included to establish the true role of sRARP in patients with recurrence after primary radiotherapy for PCa.

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Section: Discussionsupporting

confidence: 62%

Introduction of salvage prostatectomy in Denmark: the initial experience

Mortensen

Poulsen

Ahlgren³

et al. 2022

BMC Res Notes

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“…Contemporary reports detail better outcomes and lower rates. Nonetheless, approximately one in ten men still encounter prolonged postoperative leakage after sRP [18] .…”

Section: Complication Events and Managementmentioning

confidence: 99%

Nightmares in Salvage Robot-assisted Radical Prostatectomy After Primary Radiation Therapy for Prostate Cancer: A Step by Step Tutorial

Marquis

Marra²,

Calleris³

et al. 2022

European Urology Open Science

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“…Rectal injuries are now rare (<1%–2%), and strictures also diminished (<10%–20%). However, currently, one in ten and one in three men still experience high-grade and overall complications, respectively ( 14 – 16 ); despite almost 60% of men preserving their pre-operative continence status, up to one in four still has severe (>3 pads/day) incontinence.…”

Section: Introductionmentioning

confidence: 99%

The SAFE Pilot Trial—SAlvage Focal Irreversible Electroporation—For Recurrent Localized Prostate Cancer: Rationale and Study Protocol

et al. 2022

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IntroductionCurrently, the majority of prostate cancer (PCa) recurrences after non-surgical first-line treatment are managed with androgen-deprivation therapy (ADT). Salvage radical prostatectomy (sRP) is a curative alternative to ADT but yields significant morbidity. Preliminary evidence from focal salvage treatments shows similar oncological control but lower morbidity compared to sRP. Among available ablative focal energies, irreversible electroporation (IRE) is a treatment modality that proved promising, especially in treating apical lesions, where PCa most often recurs. Our aim is to test the safety of salvage IRE for recurrent PCa.MethodsWe performed a single-arm pilot feasibility study (IDEAL stage 2a): SAFE, SAlvage Focal irreversible Electroporation for recurrent localized PCa. Twenty patients with biopsy-proven PCa recurrence after primary non-surgical (radiation or ablation) treatment were included. All men will undergo mpMRI ± targeted biopsies, pre-operative PSMA-PET staging before inclusion and sIRE. Outcomes will be evaluated through internationally validated questionnaires and morbidity scales. All men will undergo a control biopsy at one year.ResultsPrimary objectives were the evaluation of the safety of sIRE (and patients’ quality of life) after treatment. Secondary objectives were the evaluation of functional outcomes, namely, continence and erectile function changes and evaluation of short-term oncological efficacy.ConclusionsSAFE is the second pilot study to evaluate sIRE and the first one performed according to the most recent diagnostic and staging imaging standards. sIRE may provide a curative option for recurrent PCa together with lower comorbidities compared to sRP.

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Oncological outcomes of salvage radical prostatectomy for recurrent prostate cancer in the contemporary era: A multicenter retrospective study

Cited by 27 publications

References 23 publications

Introduction of salvage prostatectomy in Denmark: the initial experience

Introduction of salvage prostatectomy in Denmark: the initial experience

Nightmares in Salvage Robot-assisted Radical Prostatectomy After Primary Radiation Therapy for Prostate Cancer: A Step by Step Tutorial

The SAFE Pilot Trial—SAlvage Focal Irreversible Electroporation—For Recurrent Localized Prostate Cancer: Rationale and Study Protocol

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