Oncogenicity study of trifluralin in B6C3F1 mice

Treatment of Experimental Chronic Chagas Disease with Trifluralin

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella/microsome mutagenicity test, the yeast genotoxicity assay, the mouse lymphoma assay, the sister chromatid exchange assay, the in vitro chromosome aberration assay, and the in vivo micronucleus test for mammalian genotoxicity (Humburg 1989; Garriott et al 1991; Ebert et al 1992). Oncogenicity tests in rats and mice and embryotoxicity tests in rats and rabbits revealed neither carcinogenic nor teratogenic potential when taken orally (Francis et al 1991; Ebert et al 1992). In addition tubulins, as new targets affected by trifluralin, are encoded by multiple copies of genes, and thus drug resistance may be less likely to develop (Croft 1988; Fairlamb 1989; Seeback et al 1990).…”

Treatment of Experimental Chronic Chagas Disease with Trifluralin

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella/microsome mutagenicity test, the yeast genotoxicity assay, the mouse lymphoma assay, the sister chromatid exchange assay, the in vitro chromosome aberration assay, and the in vivo micronucleus test for mammalian genotoxicity (Humburg 1989; Garriott et al 1991; Ebert et al 1992). Oncogenicity tests in rats and mice and embryotoxicity tests in rats and rabbits revealed neither carcinogenic nor teratogenic potential when taken orally (Francis et al 1991; Ebert et al 1992). In addition tubulins, as new targets affected by trifluralin, are encoded by multiple copies of genes, and thus drug resistance may be less likely to develop (Croft 1988; Fairlamb 1989; Seeback et al 1990).…”

Trifluralin Toxicity in a Chagas Disease Mouse Model

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella /microsome mutagenicity test, the yeast genotoxicity assay, and the in vivo micronucleus test for mammalian genotoxicity [21–23]. Embryotoxicity tests in rats and rabbits revealed no potential when taken orally [23,24].…”

Herbicides to curb human parasitic infections: in vitro and in vivo effects of trifluralin on the trypanosomatid protozoans.

“…toxicity tests: the Salmonella/microsome mutagenicity test, the L5178Y mouse lymphoma assay, the sister-chromatid exchange assay, and the in vitro chromosome aberration assay (16,34). In a 2-year study in which trifluralin was fed to B6C3F1 mice, no increase of benign or malignant neoplasms was observed (35). However, the compound activated mouse liver xenobiotic-metabolizing enzymes such as glutathione S-transferase; this may account for its protective effect against benzo [alpyrene induction of lung and forestomach tumors in A/J mice (36,37).…”

Treatment of Experimental Chronic Chagas Disease with Trifluralin

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella/microsome mutagenicity test, the yeast genotoxicity assay, the mouse lymphoma assay, the sister chromatid exchange assay, the in vitro chromosome aberration assay, and the in vivo micronucleus test for mammalian genotoxicity (Humburg 1989; Garriott et al 1991; Ebert et al 1992). Oncogenicity tests in rats and mice and embryotoxicity tests in rats and rabbits revealed neither carcinogenic nor teratogenic potential when taken orally (Francis et al 1991; Ebert et al 1992). In addition tubulins, as new targets affected by trifluralin, are encoded by multiple copies of genes, and thus drug resistance may be less likely to develop (Croft 1988; Fairlamb 1989; Seeback et al 1990).…”

Trifluralin Toxicity in a Chagas Disease Mouse Model

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella /microsome mutagenicity test, the yeast genotoxicity assay, and the in vivo micronucleus test for mammalian genotoxicity [21–23]. Embryotoxicity tests in rats and rabbits revealed no potential when taken orally [23,24].…”

Herbicides to curb human parasitic infections: in vitro and in vivo effects of trifluralin on the trypanosomatid protozoans.

“…toxicity tests: the Salmonella/microsome mutagenicity test, the L5178Y mouse lymphoma assay, the sister-chromatid exchange assay, and the in vitro chromosome aberration assay (16,34). In a 2-year study in which trifluralin was fed to B6C3F1 mice, no increase of benign or malignant neoplasms was observed (35). However, the compound activated mouse liver xenobiotic-metabolizing enzymes such as glutathione S-transferase; this may account for its protective effect against benzo [alpyrene induction of lung and forestomach tumors in A/J mice (36,37).…”

Treatment of Experimental Chronic Chagas Disease with Trifluralin

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella/microsome mutagenicity test, the yeast genotoxicity assay, the mouse lymphoma assay, the sister chromatid exchange assay, the in vitro chromosome aberration assay, and the in vivo micronucleus test for mammalian genotoxicity (Humburg 1989; Garriott et al 1991; Ebert et al 1992). Oncogenicity tests in rats and mice and embryotoxicity tests in rats and rabbits revealed neither carcinogenic nor teratogenic potential when taken orally (Francis et al 1991; Ebert et al 1992). In addition tubulins, as new targets affected by trifluralin, are encoded by multiple copies of genes, and thus drug resistance may be less likely to develop (Croft 1988; Fairlamb 1989; Seeback et al 1990).…”

Trifluralin Toxicity in a Chagas Disease Mouse Model

“…Trifluralin is not genotoxic, as indicated by the standard tests, such as the Salmonella /microsome mutagenicity test, the yeast genotoxicity assay, and the in vivo micronucleus test for mammalian genotoxicity [21–23]. Embryotoxicity tests in rats and rabbits revealed no potential when taken orally [23,24].…”

Herbicides to curb human parasitic infections: in vitro and in vivo effects of trifluralin on the trypanosomatid protozoans.

“…toxicity tests: the Salmonella/microsome mutagenicity test, the L5178Y mouse lymphoma assay, the sister-chromatid exchange assay, and the in vitro chromosome aberration assay (16,34). In a 2-year study in which trifluralin was fed to B6C3F1 mice, no increase of benign or malignant neoplasms was observed (35). However, the compound activated mouse liver xenobiotic-metabolizing enzymes such as glutathione S-transferase; this may account for its protective effect against benzo [alpyrene induction of lung and forestomach tumors in A/J mice (36,37).…”