Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis

Open-Label Prospective Randomized Comparative Study of the Efficacy and Safety of Gentamicin in Comparison to Other Antibiotics in the Management of Acute Appendicitis in Surgically Treated Patients

“…The absence of nephrotoxicity in our study could be related to short treatment courses and the lower nephrotoxicity of a single-dose regimen compared to multiple-daily dosing that was used in older studies. Aminoglycosides in a single daily dose were reported to be safer than in a multiple-dosing regimen [ 14 , 17 ]. An older study by Prins et al resulted in 5% renal impairment in patients receiving once-daily aminoglycoside and 24% in patients receiving it three times daily ( p = 0.016).…”

Open-Label Prospective Randomized Comparative Study of the Efficacy and Safety of Gentamicin in Comparison to Other Antibiotics in the Management of Acute Appendicitis in Surgically Treated Patients

“…The absence of nephrotoxicity in our study could be related to short treatment courses and the lower nephrotoxicity of a single-dose regimen compared to multiple-daily dosing that was used in older studies. Aminoglycosides in a single daily dose were reported to be safer than in a multiple-dosing regimen [ 14 , 17 ]. An older study by Prins et al resulted in 5% renal impairment in patients receiving once-daily aminoglycoside and 24% in patients receiving it three times daily ( p = 0.016).…”

Wideband Middle-Ear Measures in Aminoglycoside-Exposed Adults with Cystic Fibrosis

“…Each participant with CF was assigned to one of three IV-AG exposure groups using a cumulative-weighted dose method in which all individual IV-AG doses were summed and weighted by the frequency of dosing per day. More frequent dosing per day received a higher weight than one dose per day due to drug clearance factors in CF shown to increase toxicities ( Garinis et al, 2017 ; Smyth et al, 2017 ).…”

Optimizing Antibiotic Drug Therapy in Pediatrics: Current State and Future Needs

“…55,56 The efficacy and safety of extended-interval dosing was compared to traditional thrice-daily dosing of tobramycin at 10 or 15 mg/kg/day in a meta-analysis of four randomized, controlled studies that evaluated both pediatric and adult participants with CF. 61 No significant differences in clinical outcomes (including pulmonary function, nutritional status, time to first pulmonary exacerbation after treatment course, and ototoxicity) were reported between these dosing strategies. However, the advantage of the extended-interval dosing strategy was decreased nephrotoxicity, defined by serum creatinine and urinary renal biomarkers.…”

Open-Label Prospective Randomized Comparative Study of the Efficacy and Safety of Gentamicin in Comparison to Other Antibiotics in the Management of Acute Appendicitis in Surgically Treated Patients

“…The absence of nephrotoxicity in our study could be related to short treatment courses and the lower nephrotoxicity of a single-dose regimen compared to multiple-daily dosing that was used in older studies. Aminoglycosides in a single daily dose were reported to be safer than in a multiple-dosing regimen [ 14 , 17 ]. An older study by Prins et al resulted in 5% renal impairment in patients receiving once-daily aminoglycoside and 24% in patients receiving it three times daily ( p = 0.016).…”

Wideband Middle-Ear Measures in Aminoglycoside-Exposed Adults with Cystic Fibrosis

“…Each participant with CF was assigned to one of three IV-AG exposure groups using a cumulative-weighted dose method in which all individual IV-AG doses were summed and weighted by the frequency of dosing per day. More frequent dosing per day received a higher weight than one dose per day due to drug clearance factors in CF shown to increase toxicities ( Garinis et al, 2017 ; Smyth et al, 2017 ).…”

Optimizing Antibiotic Drug Therapy in Pediatrics: Current State and Future Needs

“…55,56 The efficacy and safety of extended-interval dosing was compared to traditional thrice-daily dosing of tobramycin at 10 or 15 mg/kg/day in a meta-analysis of four randomized, controlled studies that evaluated both pediatric and adult participants with CF. 61 No significant differences in clinical outcomes (including pulmonary function, nutritional status, time to first pulmonary exacerbation after treatment course, and ototoxicity) were reported between these dosing strategies. However, the advantage of the extended-interval dosing strategy was decreased nephrotoxicity, defined by serum creatinine and urinary renal biomarkers.…”

Open-Label Prospective Randomized Comparative Study of the Efficacy and Safety of Gentamicin in Comparison to Other Antibiotics in the Management of Acute Appendicitis in Surgically Treated Patients

“…The absence of nephrotoxicity in our study could be related to short treatment courses and the lower nephrotoxicity of a single-dose regimen compared to multiple-daily dosing that was used in older studies. Aminoglycosides in a single daily dose were reported to be safer than in a multiple-dosing regimen [ 14 , 17 ]. An older study by Prins et al resulted in 5% renal impairment in patients receiving once-daily aminoglycoside and 24% in patients receiving it three times daily ( p = 0.016).…”

Wideband Middle-Ear Measures in Aminoglycoside-Exposed Adults with Cystic Fibrosis

“…Each participant with CF was assigned to one of three IV-AG exposure groups using a cumulative-weighted dose method in which all individual IV-AG doses were summed and weighted by the frequency of dosing per day. More frequent dosing per day received a higher weight than one dose per day due to drug clearance factors in CF shown to increase toxicities ( Garinis et al, 2017 ; Smyth et al, 2017 ).…”

Optimizing Antibiotic Drug Therapy in Pediatrics: Current State and Future Needs

“…55,56 The efficacy and safety of extended-interval dosing was compared to traditional thrice-daily dosing of tobramycin at 10 or 15 mg/kg/day in a meta-analysis of four randomized, controlled studies that evaluated both pediatric and adult participants with CF. 61 No significant differences in clinical outcomes (including pulmonary function, nutritional status, time to first pulmonary exacerbation after treatment course, and ototoxicity) were reported between these dosing strategies. However, the advantage of the extended-interval dosing strategy was decreased nephrotoxicity, defined by serum creatinine and urinary renal biomarkers.…”