2014
DOI: 10.3389/fpls.2014.00177
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Abstract: In plants, small non-coding RNAs (≈20–30 nt) play a major role in a gene regulation mechanism that controls development, maintains heterochromatin and defends against viruses. However, their possible role in cell division (mitosis and meiosis) still remains to be ascertained. ARGONAUTE (AGO) proteins are key players in the different small RNA (sRNA) pathways. Arabidopsis contains 10 AGO proteins belonging to three distinct phylogenetic clades based on amino acid sequence, namely: AGO1/AGO5/AGO10, AGO2/AGO3/AGO… Show more

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Cited by 50 publications
(51 citation statements)
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“…Furthermore, both Dicer and AGO mutants in S. pombe are synthetic lethal with the key homologous repair protein Rad51 and have DNA damage response phenotypes 141 . Both AGO2 and AGO9 have a detectable effect on DNA repair efficiency in A. thaliana 138,142 , where 21- and 24-nucleotide double-strand-break-induced siRNAs (diRNAs) are induced in the vicinity of double strand breaks (DSBs) and are produced by DCL2, DCL3 and DCL4 138 . The additional requirement of RDRs and Pol IV for diRNA biogenesis also suggests that de novo transcription and dsRNA amplification mechanisms are involved in DSB repair, although small amounts of diRNAs provide sufficient repair capacity in the absence of RDRs 138 .…”
Section: Nuclear Functions Of Small Rnasmentioning
confidence: 99%
“…Furthermore, both Dicer and AGO mutants in S. pombe are synthetic lethal with the key homologous repair protein Rad51 and have DNA damage response phenotypes 141 . Both AGO2 and AGO9 have a detectable effect on DNA repair efficiency in A. thaliana 138,142 , where 21- and 24-nucleotide double-strand-break-induced siRNAs (diRNAs) are induced in the vicinity of double strand breaks (DSBs) and are produced by DCL2, DCL3 and DCL4 138 . The additional requirement of RDRs and Pol IV for diRNA biogenesis also suggests that de novo transcription and dsRNA amplification mechanisms are involved in DSB repair, although small amounts of diRNAs provide sufficient repair capacity in the absence of RDRs 138 .…”
Section: Nuclear Functions Of Small Rnasmentioning
confidence: 99%
“…Arabidopsis thaliana AGO5 (AtAGO5), related to rice MEL1, is believed to function in female gametogenesis, since a semi-dominant ago5 - 4 mutant is defective in the initiation of mega-gametogenesis (Borges et al 2011; Tucker et al 2012). AtAGO2 is involved in somatic DNA repair, and also in chiasma frequency in PMC (Oliver et al 2014; Wei et al 2012). AtAGO9, which interacts with 24-nt rasiRNAs, restricts the number of spore mother cells in somatic cells of an ovule, suppresses the activity of transposable elements, and is also responsible for the frequency of chromosome interlocks in meiosis in PMC (Oliver et al 2014; Olmedo-Monfil et al 2010).…”
Section: Introductionmentioning
confidence: 99%
“…However, it is also apparent that the RNAi machinery seems to be dispensable for cellular life since it has been entirely lost or extensively modified in several species. In a wide range of eukaryotes, sRNA-mediated mechanisms have been implicated in multiple processes including transposon silencing, resistance to viruses, regulation of endogenous gene expression, heterochromatin formation, DNA methylation, DNA repair, and maintenance of genome stability (Cerutti and Casas-Mollano, 2006;Carthew and Sontheimer, 2009;Ohsawa et al, 2013;Rogers and Chen, 2013;Oliver et al, 2014;Zhong et al, 2014). In contrast, very little is known about the actual function(s) of RNA-mediated silencing in microalgae.…”
Section: Biological Role(s) Of Rna Interferencementioning
confidence: 99%
“…Yet, in slightly over a decade, RNAi has evolved into a fascinating biological phenomenon intersecting with multiple cellular pathways. Indeed, histone post-translational modifications, DNA cytosine methylation, and RNA-mediated mechanisms impinge on many cellular processes including, besides regulation of gene expression, DNA repair and recombination, chromatin structure, chromosome condensation/stability, as well as the suppression of viruses and transposable elements (Cerutti and Casas-Mollano, 2006;Carthew and Sontheimer, 2009;Cerutti et al, 2011;Ohsawa et al, 2013;Oliver et al, 2014). Moreover, gene silencing mechanisms seem to be important for the integration of environmental and intrinsic stimuli in the control of gene expression and their disruption leads to physiological and developmental abnormalities (Bannister and Kouzarides, 2011;Ohsawa et al, 2013).…”
Section: Introductionmentioning
confidence: 99%