On the Nature of the Eczematogenic Component of Oxidized δ3-carene*

Impact of different storage conditions on the quality of selected essential oils

“…Effect of varying storage conditions on physico-chemical properties and HPLC-fingerprints of selected essential oils Determination of POV has been formerly proposed for quality control of essential oils (Wabner, 2002). To some degree, POVs reflect the amount of oxidizing compounds in the oil at the time of measurement such as hydroperoxides, which themselves have been considered responsible for allergic skin reactions to flavoring materials (Hagvall et al, 2007;Hellerström, Thyresson, Blohm, & Widmark, 1955;Karlberg, Shao, Nilsson, Gäfvert, & Nilsson, 1994;Pirilä & Siltanen, 1958;Sköld et al, 2004). However, decreasing values due to peroxide degradation into more stable oxidized secondary products have been reported (e.g., Bernhard & Marr, 1960;Haddouchi et al, 2011;Pirilä & Siltanen, 1958), feigning a false state of freshness of the sample analyzed.…”

On the Chemical Nature of the Eczematogenic Agent in Oil of Turpentine

“…By V. P IR IL A , E. SILTANEN and LOUNA PIR ILA The sensitizing effect of oil of turpentine has been thoroughly studied in recent years by Hellerström et al [2,3,4,5] as well as by Pirilä et al [6,8,9,10,11]. These team s, using somewhat differing methods, have on m any points reached practically the same conclu sions.…”

On the Chemical Nature of the Eczematogens in Oil of Turpentine

“…Since the autoxidation products of 3-carene had been shown to cause the strongest reactions in patients sensitized to oil of turpentine and since, in addition, the eczematogenic effects ol samples of 3-carene oxidized to different degrees closely paralleled the respective hydroperoxide concentrations [6,19], 3-carene was chosen as the basis of comparison indicating its eczematogenic effect (per hydroperoxide content) with 1 (Tab. II).…”