2018
DOI: 10.1038/s41598-018-26629-5
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Abstract: While age-related macular degeneration (AMD) poses an important personal and public health burden, comparing epidemiological studies on AMD is hampered by differing approaches to classify AMD. In our AugUR study survey, recruiting residents from in/around Regensburg, Germany, aged 70+, we analyzed the AMD status derived from color fundus images applying two different classification systems. Based on 1,040 participants with gradable fundus images for at least one eye, we show that including individuals with onl… Show more

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Cited by 34 publications
(68 citation statements)
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“…We found five and three genes, respectively, expressed in adult retina and adult RPE cells ( CD46, PLXNA2, CR1, CD34, CD55 ; TYR, GRM5, NOX4 ; Figure S7-S8 ). (5) When querying the 17 genes in the Mouse Genome Informatics, MGI (33) or Online Mendelian Inheritance in Man, OMIM ® , database, for eye phenotypes in mice or humans, we identified relevant eye phenotypes for five genes in mice ( CD46, CR1, CR1L, PLXNA2; TYR ; Table S8 ) and for one gene in human ( TYR; Table S9 ).…”
Section: Resultsmentioning
confidence: 99%
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“…We found five and three genes, respectively, expressed in adult retina and adult RPE cells ( CD46, PLXNA2, CR1, CD34, CD55 ; TYR, GRM5, NOX4 ; Figure S7-S8 ). (5) When querying the 17 genes in the Mouse Genome Informatics, MGI (33) or Online Mendelian Inheritance in Man, OMIM ® , database, for eye phenotypes in mice or humans, we identified relevant eye phenotypes for five genes in mice ( CD46, CR1, CR1L, PLXNA2; TYR ; Table S8 ) and for one gene in human ( TYR; Table S9 ).…”
Section: Resultsmentioning
confidence: 99%
“…(4) Retinal expression: We queried the EyeIntegration database to evaluate genes in the relevant loci for expression in fetal or adult retina or RPE cells (32). (5) Animal model: We queried the Mouse Genome Informatics (MGI) database (www.informatics.jax.org) for each gene in the relevant loci for relevant eye phenotypes in mice (33). (6) Human phenotype: The Online Mendelian Inheritance in Man (OMIM) ® database was queried for human eye phenotypes (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, queried 07/11/2019, www.omim.org).…”
Section: Methodsmentioning
confidence: 99%
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“…Early and advanced AMD can be documented by color fundus imaging of the central retina and/or other multimodal imaging approaches including optical coherence tomography (OCT) [1][2][3]. While the definition of advanced AMD is reasonably homogeneous across clinical and epidemiological studies, the classification of early AMD is more variable and different studies traditionally apply differing classification systems [4,5].…”
Section: (Continued From Previous Page)mentioning
confidence: 99%
“…The standard in epidemiological studies is to collect colour fundus images of the participants' eyes, which are then manually classified as a disease stage according to standardised protocols. There are various classification systems that differ in their definition of early AMD stages and it is still subject of research which definition of early disease stages predicts progression towards late AMD best (Klein et al., ; Brandl et al., ). All stages of AMD can appear in neither, one, or both eyes of a study participant; it is also possible that both forms of late AMD occur in the same single eye.…”
Section: Introductionmentioning
confidence: 99%