On the hepatotoxicity of 1,1,2,2-tetrachloroethane

Changes of serum biochemical parameters and liver pathology in 18 patients with 1,1,2,2‐tetrachloroethane‐induced hepatotoxicity

“…[23][24][25] Both nuclear and microsomal cytochrome P450 (CYP) enzymes are involved in the metabolism of the compound, possibly releasing a number of biologically active compounds including aldehydes, alkene acids and free radicals, especially in the tissue which is high in metabolic capacity such as the liver. Paolini et al 1 also found that TTCE metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation and attendant hepatotoxic effects. Colacci et al 26 observed that in vivo TTCE binds to DNA in the liver and other organs in rats and mice, indicating its genotoxicity.…”

“…1,1,2,2‐tetrachloroethane (TTCE) is a colorless incombustible manufactured chemical. It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals 1 . TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use 2 .…”

“…It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals. 1 TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use. 2 Immediately after World War I, hepatotoxicity and neurological distress were reported in workers exposed to varnish containing TTCE which was used to cover fabric wings of aeroplanes.…”

Changes of serum biochemical parameters and liver pathology in 18 patients with 1,1,2,2‐tetrachloroethane‐induced hepatotoxicity

“…[23][24][25] Both nuclear and microsomal cytochrome P450 (CYP) enzymes are involved in the metabolism of the compound, possibly releasing a number of biologically active compounds including aldehydes, alkene acids and free radicals, especially in the tissue which is high in metabolic capacity such as the liver. Paolini et al 1 also found that TTCE metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation and attendant hepatotoxic effects. Colacci et al 26 observed that in vivo TTCE binds to DNA in the liver and other organs in rats and mice, indicating its genotoxicity.…”

“…1,1,2,2‐tetrachloroethane (TTCE) is a colorless incombustible manufactured chemical. It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals 1 . TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use 2 .…”

“…It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals. 1 TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use. 2 Immediately after World War I, hepatotoxicity and neurological distress were reported in workers exposed to varnish containing TTCE which was used to cover fabric wings of aeroplanes.…”

Reporting transient molecular events by DNA strand displacement

“…One approach is to couple the transient event of interest with a permanent (or long-life) chemical reaction. 1 In this work, we have applied this concept to detect C-containing DNA triplex formation in neutral solutions. DNA triplexes can form in cells and are believed to be involved in some biological processes.…”

Measurement of Oxidative Stress by Epr Radical-Probe Technique

“…Because Trolox is a known substrate for peroxidase [30], inhibition may arise also from Trolox competing with the hydroxylamine I for peroxidases present in the system. Scheme 4 formed upon addition of SOD to the system suggested that our probe would selectively detect Superoxide in hepatic microsome preparations from mice [23], subsequent studies revealed that this is not actually the case [24]. Although in early investigations experiments per-As an example, the rate constant for the reaction with peroxyl radicals is 1.1 X 10 6 IVTV at 303 K in styrene [27], with alkoxyl radicals k = 1.8 X 10 9 M _1 s _1 at 298 K in water [28], and with primary alkyl radicals it can be considered very similar to the value of 6.0 X 10 5 M" measured for cx-tocopherol at 298 K in toluene [29].…”

Changes of serum biochemical parameters and liver pathology in 18 patients with 1,1,2,2‐tetrachloroethane‐induced hepatotoxicity

“…[23][24][25] Both nuclear and microsomal cytochrome P450 (CYP) enzymes are involved in the metabolism of the compound, possibly releasing a number of biologically active compounds including aldehydes, alkene acids and free radicals, especially in the tissue which is high in metabolic capacity such as the liver. Paolini et al 1 also found that TTCE metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation and attendant hepatotoxic effects. Colacci et al 26 observed that in vivo TTCE binds to DNA in the liver and other organs in rats and mice, indicating its genotoxicity.…”

“…1,1,2,2‐tetrachloroethane (TTCE) is a colorless incombustible manufactured chemical. It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals 1 . TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use 2 .…”

“…It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals. 1 TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use. 2 Immediately after World War I, hepatotoxicity and neurological distress were reported in workers exposed to varnish containing TTCE which was used to cover fabric wings of aeroplanes.…”

Reporting transient molecular events by DNA strand displacement

“…One approach is to couple the transient event of interest with a permanent (or long-life) chemical reaction. 1 In this work, we have applied this concept to detect C-containing DNA triplex formation in neutral solutions. DNA triplexes can form in cells and are believed to be involved in some biological processes.…”

Measurement of Oxidative Stress by Epr Radical-Probe Technique

“…Because Trolox is a known substrate for peroxidase [30], inhibition may arise also from Trolox competing with the hydroxylamine I for peroxidases present in the system. Scheme 4 formed upon addition of SOD to the system suggested that our probe would selectively detect Superoxide in hepatic microsome preparations from mice [23], subsequent studies revealed that this is not actually the case [24]. Although in early investigations experiments per-As an example, the rate constant for the reaction with peroxyl radicals is 1.1 X 10 6 IVTV at 303 K in styrene [27], with alkoxyl radicals k = 1.8 X 10 9 M _1 s _1 at 298 K in water [28], and with primary alkyl radicals it can be considered very similar to the value of 6.0 X 10 5 M" measured for cx-tocopherol at 298 K in toluene [29].…”

Changes of serum biochemical parameters and liver pathology in 18 patients with 1,1,2,2‐tetrachloroethane‐induced hepatotoxicity

“…[23][24][25] Both nuclear and microsomal cytochrome P450 (CYP) enzymes are involved in the metabolism of the compound, possibly releasing a number of biologically active compounds including aldehydes, alkene acids and free radicals, especially in the tissue which is high in metabolic capacity such as the liver. Paolini et al 1 also found that TTCE metabolism could result in the reductive formation of radical products, leading to the stimulation of lipid peroxidation and attendant hepatotoxic effects. Colacci et al 26 observed that in vivo TTCE binds to DNA in the liver and other organs in rats and mice, indicating its genotoxicity.…”

“…1,1,2,2‐tetrachloroethane (TTCE) is a colorless incombustible manufactured chemical. It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals 1 . TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use 2 .…”

“…It is volatile with a sweet odor and is usually used as a solvent in the production of electronics and pesticides, or as an intermediate in the production of other chemicals. 1 TTCE can cause serious hepatotoxicity among occupationally exposed people before it was revealed as a hepatotoxic hazard, and is confined in industrial use. 2 Immediately after World War I, hepatotoxicity and neurological distress were reported in workers exposed to varnish containing TTCE which was used to cover fabric wings of aeroplanes.…”

Reporting transient molecular events by DNA strand displacement

“…One approach is to couple the transient event of interest with a permanent (or long-life) chemical reaction. 1 In this work, we have applied this concept to detect C-containing DNA triplex formation in neutral solutions. DNA triplexes can form in cells and are believed to be involved in some biological processes.…”

Measurement of Oxidative Stress by Epr Radical-Probe Technique

“…Because Trolox is a known substrate for peroxidase [30], inhibition may arise also from Trolox competing with the hydroxylamine I for peroxidases present in the system. Scheme 4 formed upon addition of SOD to the system suggested that our probe would selectively detect Superoxide in hepatic microsome preparations from mice [23], subsequent studies revealed that this is not actually the case [24]. Although in early investigations experiments per-As an example, the rate constant for the reaction with peroxyl radicals is 1.1 X 10 6 IVTV at 303 K in styrene [27], with alkoxyl radicals k = 1.8 X 10 9 M _1 s _1 at 298 K in water [28], and with primary alkyl radicals it can be considered very similar to the value of 6.0 X 10 5 M" measured for cx-tocopherol at 298 K in toluene [29].…”