Local interstellar spectra (LIS) of primary cosmic ray (CR) nuclei, such as helium, oxygen, and mostly primary carbon are derived for the rigidity range from 10 MV to ∼200 TV using the most recent experimental results combined with the state-of-the-art models for CR propagation in the Galaxy and in the heliosphere. Two propagation packages, GALPROP and HELMOD, are combined into a single framework that is used to reproduce direct measurements of CR species at different modulation levels, and at both polarities of the solar magnetic field. The developed iterative maximum-likelihood method uses GALPROP-predicted LIS as input to HELMOD, which provides the modulated spectra for specific time periods of the selected experiments for model-data comparison. The interstellar and heliospheric propagation parameters derived in this study are consistent with our prior analyses using the same methodology for propagation of CR protons, helium, antiprotons, and electrons. The resulting LIS accommodate a variety of measurements made in the local interstellar space (Voyager 1) and deep inside the heliosphere at low (ACE/CRIS, HEAO-3) and high energies (PAMELA, AMS-02).that is mapping the all-sky diffuse γ-ray emission produced by CR interactions in the interstellar medium (ISM) and in the vicinity of CR accelerators.Primary nuclei, such as helium, oxygen, and mostly primary carbon, are the most abundant species in CRs after hydrogen and are the priority targets for CR missions. They are also the most abundant in the Universe, thanks to the primordial nucleosynthesis of helium and stellar nucleosynthesis that provides the heavier species. Their fragmentation in CRs produces the majority of lighter nuclides and is the main source of lithium, beryllium, and boron, which are termed "secondary." The ratios of secondary-to-primary species in CRs can be used to study properties of CR propagation in the Galaxy and provide a basis for other related studies, such as processes of particle acceleration, CR sources, properties of the ISM, search for signatures of new physics, and many others. Therefore, the LIS of helium, carbon, and oxygen are of considerable interest for astrophysics and particle physics.Recently we demonstrated that by combining two packages, GALPROP for interstellar propagation, and HELMOD for heliospheric propagation, into a single framework we were able to reproduce the direct measurements of CR protons, helium, antiprotons, and electrons (Boschini et al. 2017b(Boschini et al. , 2018 made by Voyager 1, BESS, PAMELA, AMS-01, and AMS-02 at different modulation levels, and at both polarities of the solar magnetic field. The employed iterative method uses GALPROP-predicted LIS as input to HELMOD, which provides the modulated spectra for specific time periods of the selected experiments for model-data comparison. The derived LIS of CR species can be used to facilitate significantly studies of CR propagation in the Galaxy and in the heliosphere by disentangling these two massive tasks and will lead to further progress in under...