2010
DOI: 10.1086/654815
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Abstract: These observations prompt a modification of the current paradigms of the pathogenesis of malaria and clear the way to investigate the pathophysiology of P. vivax infections.

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Cited by 272 publications
(294 citation statements)
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“…25 In addition, recent studies report cytoadherence of P. vivax-infected erythrocytes to endothelial receptors. 26 Furthermore, microrheologic research showed increased aggregation, agglutination, and reduction in deformability of P. vivax-infected erythrocytes. 27 Patients infected with P. vivax showed increased levels of interferon-γ and tumor necrosis factor showed a linear correlation with the possibility of developing severe malaria.…”
Section: Discussionmentioning
confidence: 99%
“…25 In addition, recent studies report cytoadherence of P. vivax-infected erythrocytes to endothelial receptors. 26 Furthermore, microrheologic research showed increased aggregation, agglutination, and reduction in deformability of P. vivax-infected erythrocytes. 27 Patients infected with P. vivax showed increased levels of interferon-γ and tumor necrosis factor showed a linear correlation with the possibility of developing severe malaria.…”
Section: Discussionmentioning
confidence: 99%
“…Os valores de HT, HB e do número de eritrócitos foram menores apenas nos indivíduos com alta carga parasitária, o que já é conhecido e descrito na literatura 17,23 . Sabe-se que o aumento da carga parasitária pode acarretar diminuição no número de GV, devido à ruptura dessas células durante os ciclos assexuados, ao sequestro de hemácias infectadas pelo baço e à formação de rosetas 27,28,29 .…”
Section: Discussionunclassified
“…Pregnant women are also more likely to experience relapses than non-pregnant ones [44]. P. vivax sequestration has been proposed [10], and recent reports indicate disproportional organ-specific and peripheral blood parasitaemia [42]. As for the dynamics of infection throughout pregnancy, no studies have addressed the issue.…”
Section: Dynamics Of Gestational and Placental Malariamentioning
confidence: 99%
“…In subsequent pregnancies, as immunity against placental-adherent strains develops, there is a reduced risk of adverse effects of malaria on the mother and fetus [6] and asymptomatic parasitaemia is common [7]. In the case of vivax malaria, with increasing reports of severe cases in Asia and South America [8,9], the consequences of infection during pregnancy remain to be elucidated, although adherence to endothelial cells [10] and sequestration of infected red blood cells in deep vasculature have been recently demonstrated [11,12].…”
Section: Introductionmentioning
confidence: 99%