On-line correction and visualization of motion during MRI-controlled hyperthermia

Zwart, Jacco A. de; Vimeux, Frédéric C.; Palussière, Jean; Salomir, Rarès; Quesson, Bruno; Delalande, Christophe; Moonen, Chrit

doi:10.1002/1522-2594(200101)45:1<128::aid-mrm1017>3.0.co;2-m

Cited by 85 publications

(69 citation statements)

References 30 publications

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“…If the resulting temporal resolution is inadequate to monitor the thermal treatment, echo shifting can be applied, which leads to a TR Ͻ TE in fast gradient echo sequences (57). Echo-shifting can be combined with multishot echoplanar imaging, which is then called principles of echo shifting with a train of observations (PRESTO) (87).…”

Section: Pulse Sequencesmentioning

confidence: 99%

“…Respiratory gating during free breathing has also been used (94), but gating can fail when the respiratory cycle is irregular, leading to motion artifacts and errors in the temperature maps (84). Others have described motion detection and movement registration with navigator echoes for displacements of ex vivo tissue (87). However, the use of navigator echoes is restricted to rigid body motion and may not be optimal for complex organ displacements or deformations.…”

Section: Prf Thermometry and Motionmentioning

confidence: 99%

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MR thermometry

Rieke

Pauly

2008

Magnetic Resonance Imaging

1,006

952

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Minimally invasive thermal therapy as local treatment of benign and malignant diseases has received increasing interest in recent years. Safety and efficacy of the treatment require accurate temperature measurement throughout the thermal procedure. Noninvasive temperature monitoring is feasible with magnetic resonance (MR) imaging based on temperature-sensitive MR parameters such as the proton resonance frequency (PRF), the diffusion coefficient (D), T 1 and T 2 relaxation times, magnetization transfer, the proton density, as well as temperature-sensitive contrast agents. In this article the principles of temperature measurements with these methods are reviewed and their usefulness for monitoring in vivo procedures is discussed. Whereas most measurements give a temperature change relative to a baseline condition, temperature-sensitive contrast agents and spectroscopic imaging can provide absolute temperature measurements. The excellent linearity and temperature dependence of the PRF and its near independence of tissue type have made PRF-based phase mapping methods the preferred choice for many in vivo applications. Accelerated MRI imaging techniques for real-time monitoring with the PRF method are discussed. Special attention is paid to acquisition and reconstruction methods for reducing temperature measurement artifacts introduced by tissue motion, which is often unavoidable during in vivo applications.

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Section: Pulse Sequencesmentioning

confidence: 99%

Section: Prf Thermometry and Motionmentioning

confidence: 99%

MR thermometry

Rieke

Pauly

2008

Magnetic Resonance Imaging

1,006

952

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“…Recent techniques based on the use of additional information [6] [7] have been proposed to address step 1 and/or step 2. MR magnets now allow on-line acquisition of large data volumes.…”

Section: Introductionmentioning

confidence: 99%

An optimised multi-baseline approach for on-line MR-temperature monitoring on commodity graphics hardware

Noe

Ries

Pedersen³

et al. 2008

2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro

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Magnetic Resonance Imaging (MRI) can be used for non invasive temperature mapping and is therefore a promising tool to monitor and control interventional therapies based on thermal ablation. The Proton Resonance Frequency shift MRI technique gives an estimate of the temperature by comparing phase changes between dynamically acquired images. These temperature measurements are prone to motion induced errors however, particularly in abdominal organs due to breathing.Several computational approaches have been proposed previously to correct for these motion related errors on the measured temperature. They have required significant time to compute however, and have not been sufficiently fast for several real-time temperature mapping applications. This paper proposes to use modern graphics cards (GPUs) to assess on-line motion corrected thermal maps. The computation times obtained on the GPU are compared to an existing CPU reference implementation. An acceleration factor close to 7 was obtained for the processing of one slice (resolution 128 × 128 pixels), and higher than 21 for 12 slices, allowing a real-time implementation.

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“…Such phased array devices will develop further to their full potential through the implementation of treatment plans that include beam aberration correction (80) and the optimization of thermal dose delivery (81). Fully automatic closed-loop feedback to control heating (40,57,81,82) combined with robust motion detection and correction schemes for the MR thermometry (31)(32)(33)83) will also likely reach the clinic for MRgFUS.…”

Section: Future Development Of Technologymentioning

confidence: 99%

Current status and future potential of MRI‐guided focused ultrasound surgery

Jólesz

McDannold

2008

Magnetic Resonance Imaging

112

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The combination of the imaging abilities of magnetic resonance imaging (MRI) with the ability to delivery energy to targets deep in the body noninvasively with focused ultrasound presents a disruptive technology with the potential to significantly affect healthcare. MRI offers precise targeting, visualization, and quantification of temperature changes and the ability to immediately evaluate the treatment. By exploiting different mechanisms, focused ultrasound offers a range of therapies, ranging from thermal ablation to targeted drug delivery. This article reviews recent preclinical and tests clinical of this technology. WHILE ITS POTENTIAL has been recognized for decades (1-4), focused ultrasound (FUS) therapy has been in the incubation phase for a long time. Although it has been tested in numerous animal experiments, its widespread clinical realization has lagged, primarily due to the lack of intraprocedural accurate temperature monitoring. When the idea of MRI-guidance was introduced in connection with FUS and MRI thermometry during sonication was demonstrated (5,6), it was anticipated that MR-guided FUS surgery (MRgFUS) would be widely accepted clinically within a few years. Despite these early expectations, there has been relatively slow progress in the clinical implementation of MRgFUS.Early development concentrated primarily on breast tumors (benign fibroadenoma (7,8) and malignant breast cancer (9,10)). These early implementations of the MRgFUS technology motivated the improvement of transducer technology from single-element transducers to MRI-compatible multielement phase arrays (11). There was also significant progress in MRI thermometry and its use to monitor and control sonications. Importantly, too, methods were developed to robustly quantify temperature changes (12). At first, only 2D temperature maps were obtained by MRI to allow for accurate targeting of the beam (13). Later these thermal images were used to generate maps of the thermal dose (14) that could then be used to tailor the energy deposition using closed-loop feedback control (15). This preclinical work led to the development of the first commercial system by InSightec (Haifa, Israel), the Exablate 2000, the first implementation of a fully integrated MRgFUS system that combined a phased array transducer, a computer-controlled robotic positioner, and a workstation that integrated control based on MR thermometry.The early limited clinical trials of breast tumor treatment (8 -10,16,17) were followed by the first major clinical application: the noninvasive therapy of benign uterine fibroids (18,19). The successful Phase I trial was followed by a multicenter . These clinical trials led to the approval of this technology for the treatment of uterine fibroids in several countries, including the United States. Examples of MR thermometry and postablation imaging of a uterine fibroid ablation are shown in Figure 1.The success of uterine fibroid ablation has invigorated the entire field. Technology has rapidly improved and clinical applications ke...

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On-line correction and visualization of motion during MRI-controlled hyperthermia

Cited by 85 publications

References 30 publications

MR thermometry

MR thermometry

An optimised multi-baseline approach for on-line MR-temperature monitoring on commodity graphics hardware

Current status and future potential of MRI‐guided focused ultrasound surgery

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