Abstract. Sonino N, Fava GA, Boscaro M, Fallo F (University of Padova, Padova, University of Bologna, Bologna, Italy; and State University of New York at Buffalo, NY USA). Life events and neurocirculatory asthenia. A controlled study. J Intern Med 1998; 244: 523᎐8.
Objectives:The purpose of this study was to assess the occurrence of stressful life events in the year before the onset of neurocirculatory asthenia. Design: Case-control retrospective study. Setting: A university medical outpatient clinic. Subjects: A consecutive series of 50 patients with neurocirculatory asthenia and a control group of 50 healthy subjects, matched for sociodemographic variables, were studied. Main outcome measures: Paykel's Interview for Recent Life Events (a semistructured research interview covering 64 life events) was administered to patients and controls. Results: Patients with neurocirculatory asthenia reported significantly more stressful life events than the control group (P Ͻ 0.05) and had significantly more of the following: exits (P Ͻ 0.05), undesirable (P Ͻ 0.05) and uncontrolled (P Ͻ 0.01) events. More events that had an objective negative impact (P Ͻ 0.001) and more independent events (P ϭ 0.07) were also reported. Ratings of impact and independence were carried out by a blind rater who was unaware whether the event had occurred in patients or controls.
Conclusions:The results are suggestive of a strong relationship between stressful life events and neurocirculatory asthenia. This is in agreement with a multifactorial model of pathogenesis in neurocirculatory asthenia and with current understanding of the extensive links of behavioral responses to stress with neurophysiological and biochemical processes.