volume 37, issue 1, P1-2 2015
DOI: 10.1590/1516-4446-2015-3609
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Abstract: There is evidence that unipolar and bipolar depression are characterized by activated immune-related pathways, including increased levels of monocytic cytokines, an acute phase response, a T helper-1 shift with induction of indoleamine 2,3-dioxygenase and the tryptophan catabolite pathway (TRYCAT), oxidative and nitrosative stress (O&NS) with secondary autoimmune responses to oxidative specific epitopes and nitric-oxide adducts, immunemetabolic disorders (e.g., lipid metabolism), increased translocation of gr…

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