2021
DOI: 10.1038/s41586-021-04385-3
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Abstract: This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

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Cited by 1,378 publications
(1,102 citation statements)
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“…The Omicron (B.1.1.529) variant has been shown to be highly transmissible with decreased susceptibility to therapeutic monoclonal antibodies and neutralizing antibodies conferred by vaccination or prior infection (Flemming 2022;VanBlargan et al 2022). These characteristics are likely due to a large number of mutations in the spike protein (n=30) (Cao et al 2021). Omicron has spread to become the predominant circulating lineage worldwide as of early January 2022 amidst high background levels of Delta (B.1.617.2) variant infection (Gangavarapu et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…The Omicron (B.1.1.529) variant has been shown to be highly transmissible with decreased susceptibility to therapeutic monoclonal antibodies and neutralizing antibodies conferred by vaccination or prior infection (Flemming 2022;VanBlargan et al 2022). These characteristics are likely due to a large number of mutations in the spike protein (n=30) (Cao et al 2021). Omicron has spread to become the predominant circulating lineage worldwide as of early January 2022 amidst high background levels of Delta (B.1.617.2) variant infection (Gangavarapu et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“… 4 In the study by Wolter and colleagues, 1 the odds of previous infection were around 23-times higher in SGTF-infected versus delta variant-infected patients, which could be due to the omicron variant's capacity for immune escape that could increase the proportion of milder reinfections. 5 The possibility of some patients being hospitalised with, rather than for, SARS-CoV-2 infection could also affect severity analyses given near universal, pre-hospitalisation COVID-19 testing and the increasing population prevalence of infection. 6 …”
mentioning
confidence: 99%
“…Omicron has more than 30 mutations in the Spike protein and 15 in the receptor binding domain (RBD) of the Spike protein that binds to the uptake receptor ACE2. These include shared mutations with the Alpha, Beta, Gamma, and Delta VOCs 2,5,6,8 . These previously well-studied mutations confer increased transmissibility, higher viral binding affinity, and higher antibody escape 3,4 .…”
mentioning
confidence: 99%