Omega-3 fatty acids plus vitamin for women with gestational diabetes or prediabetes: a meta-analysis of randomized controlled studies

Jiang, Lan; Gao, Chenlin; Yan, Peiyu; Chen, Pan; Jiang, Chunxia; Xu, Yong; Chen, Muhu

doi:10.1080/14767058.2020.1814239

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Supplementation of vitamin D or E, particularly with omega-3 FAs, has been suggested to improve glycemic control, alleviate oxidative stress, and reduce triglycerides, although the incidence of macrosomic birth in women with GDM or prediabetes was not reduced [166]. These data suggest clear relationships between maternal nutrient status, glycemic control, and offspring outcomes and suggest that intervention studies that target offspring nutrient status at birth intending to improve longterm outcomes are needed.…”

Section: Background Informationmentioning

confidence: 95%

Diabetes During Pregnancy: Neonatal and Childhood Complications

Beek

2022

Comprehensive Clinical Approach to Diabetes During Pregnancy

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Highlights• Next to health risks and complications in the mother during and after pregnancy, also offspring exposed to maternal hyperglycemia is at risk for both short-and long-term complications. • In particular, the period of early growth and development after birth, up to 2-3 years of age, may provide an untapped opportunity for better monitoring, support and (nutritional) intervention programs to improve health outcomes for these children. • Specific points of attention include growth and body composition development, the development of the brain and the microbiota, and early feeding patterns, including lactation and the period of weaning. • Timely detection of possible growth deviations, including differences in adiposity development, is key as this will allow for the possible development of interventions that could reduce the risk for later overweight and obesity. • Current interventions mainly target the management and prevention of gestational diabetes (GDM) in the mother but should recognize the window of opportunity to nutritionally support the quality of child growth and metabolic health during the post-natal period.

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Section: Background Informationmentioning

confidence: 95%

Diabetes During Pregnancy: Neonatal and Childhood Complications

Beek

2022

Comprehensive Clinical Approach to Diabetes During Pregnancy

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“…In rodent models, a high fat diet (HF) rich in saturated fatty acids (SFAs) given during pregnancy induces several metabolic alterations in offspring during adulthood: liver steatosis, increased body and visceral fat mass, adipocyte hypertrophy, pro-inflammatory cytokines production, IR, pancreatic islet hypertrophy, and oxidative stress (11,12) . Long chain (LC) n-3 PUFAs, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can prevent and even decrease IR in rodents fed a HF diet, which has also been shown in humans (13)(14)(15)(16)(17)(18) . During pregnancy, the only source of PUFAs for the developing fetus is via the placenta.…”

Section: Introductionmentioning

confidence: 98%

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Guriec¹,

Foll

Delarue

2023

Br J Nutr

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This study investigated whether long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) given to pregnant rats fed a high fat (HF) diet may prevent fetal programming in male offspring at adulthood. Six weeks before mating, and throughout gestation and lactation, female nulliparous Sprague-Dawley rats were given a chow (C) diet, HF (60.6% fat from corn, rapeseed oils and lard) or HF in which one third of fat was replaced by fish oil (HF n-3). At weaning, the 3 offspring groups were randomly separated in 2 groups fed C diet, or HF without LC n-3 PUFAs, for 7 weeks until adulthood. Glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test both at weaning and at adulthood. Insulin signaling was determined in liver, muscle and adipose tissue by quantification of the phosphorylation of Akt on Ser 473 at adulthood. At weaning, as at adulthood, offspring from HF-fed dams were obese, and displayed glucose intolerance (GI) and insulin-resistance (IR), but not those from HFn-3 fed dams. Following the post-weaning C diet, phosphorylation of Akt was strongly reduced in all tissues of offspring from HF dams, but to a lesser extent in liver and muscle of offspring from HFn-3 dams. However, it was abolished in all tissues of all offspring groups fed the HF post-weaning diet. Thus, LC n-3 PUFAs introduced in a HF in dams, partially prevented the transmission of GI and IR in adult offspring even though they were fed without LC n-3 PUFAs from weaning.

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“…GDM has also been associated with low vitamin A status during pregnancy [17][18][19]. Supplementation with omega-3 fatty acids in combination with vitamin D or E can alleviate maternal oxidative stress in women with GDM or prediabetes [20] while there is no information on its effect on cord antioxidant status.…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamins A and E at Mid-Pregnancy and Their Relationships with Both Maternal and Cord Blood Antioxidant Status and Perinatal Conditions: The NELA Cohort

Sánchez-Campillo,

Gázquez,

Serrano-Munuera

et al. 2023

Ann Nutr Metab

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Introduction: Most of the pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. Methods: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain. Results: There were large discrepancies between low dietary vitamin E intake (78% of the mothers) and low serum vitamin E levels (3%) at 24 weeks of gestation. Maternal serum vitamins A and E at mid-pregnancy were associated with higher antioxidant status not only in the mother at this time point (lower hydroperoxides and higher total antioxidant activity [TAA]) but also with the newborn at birth (higher TAA). Gestational diabetes mellitus (GDM) was negatively associated with maternal serum vitamin A (OR: 0.95 CI: 0.91–0.99, p = 0.009) at mid-pregnancy. Nevertheless, we could not detect any association between GDM and oxidative stress parameters. Conclusions: In conclusion, maternal vitamin A and E serum levels may be used as an early potential biomarker of antioxidant status of the neonate at birth. Control of these vitamins during pregnancy could help avoid morbid conditions in the newborn caused by oxidative stress in GDM pregnancies.

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Omega-3 fatty acids plus vitamin for women with gestational diabetes or prediabetes: a meta-analysis of randomized controlled studies

Cited by 12 publications

References 32 publications

Diabetes During Pregnancy: Neonatal and Childhood Complications

Diabetes During Pregnancy: Neonatal and Childhood Complications

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Serum Vitamins A and E at Mid-Pregnancy and Their Relationships with Both Maternal and Cord Blood Antioxidant Status and Perinatal Conditions: The NELA Cohort

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