Omega-3 Fatty Acids and Acne—Reply

Cordain, Loren

doi:10.1001/archderm.139.7.941-a

Cited by 9 publications

(2 citation statements)

References 7 publications

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“…However, the crossover study by Fulton et al [4] was methodologically flawed by comparing chocolate and sweet vegetable oil bars that had the same glycemic index (GI). In addition, the placebo bars had higher content of partially hydrogenated vegetable fat, which may contribute to inflammation due to the trans-fatty acids [5]. This is because, in prostaglandins production, competition between trans and essential fatty acids may lead to inflammation [6].…”

Section: Introductionmentioning

confidence: 99%

High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

2012

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BackgroundThe role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults.MethodsA case–control study was conducted among 44 acne vulgaris patients and 44 controls aged 18 to 30 years from October 2010 to January 2011. Comprehensive acne severity scale (CASS) was used to determine acne severity. A questionnaire comprising items enquiring into the respondent’s family history and dietary patterns was distributed. Subjects were asked to record their food intake on two weekdays and one day on a weekend in a three day food diary. Anthropometric measurements including body weight, height and body fat percentage were taken. Acne severity was assessed by a dermatologist.ResultsCases had a significantly higher dietary glycemic load (175 ± 35) compared to controls (122 ± 28) (p < 0.001). The frequency of milk (p < 0.01) and ice-cream (p < 0.01) consumptions was significantly higher in cases compared to controls. Females in the case group had a higher daily energy intake compared to their counterparts in the control group, 1812 ± 331 and 1590 ± 148 kcal respectively (p < 0.05). No significant difference was found in other nutrient intakes, Body Mass Index, and body fat percentage between case and control groups (p > 0.05).ConclusionsGlycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris.

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Section: Introductionmentioning

confidence: 99%

High glycemic load diet, milk and ice cream consumption are related to acne vulgaris in Malaysian young adults: a case control study

2012

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“…Inflammatory mediators are predominantly released by activated leukocytes and result in inflammatory acne lesions characterized by pain, redness, and swelling [3]. Given that acne is a rare condition in non-Westernized societies with higher ratios of n-3 to n-6 from dietary intake, it appears that the lower n-3 content of the western diet is an important dietary modulator of these inflammatory mediators [1,4-6]. A case control study of Koreans found that individuals with acne consumed significantly less fish and more junk food than the control group [7].…”

Section: Introductionmentioning

confidence: 99%

Effects of fish oil supplementation on inflammatory acne

et al. 2012

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BackgroundGiven that acne is a rare condition in societies with higher consumption of omega-3 (n-3) relative to omega-6 (n-6) fatty acids, supplementation with n-3 may suppress inflammatory cytokine production and thereby reduce acne severity.Methods13 individuals with inflammatory acne were given three grams of fish oil containing 930 mg of EPA to their unchanged diet and existing acne remedies for 12 weeks. Acne was assessed using an overall severity grading scale, total inflammatory lesion counts, and colorimetry.FindingsThere was no significant change in acne grading and inflammatory counts at week 12 compared to baseline. However, there was a broad range of response to the intervention on an individual basis. The results showed that acne severity improved in 8 individuals, worsened in 4, and remained unchanged in 1. Interestingly, among the individuals who showed improvement, 7 were classified as having moderate to severe acne at baseline, while 3 of the 4 whose acne deteriorated were classified as having mild acne.ConclusionThere is some evidence that fish oil supplementation is associated with an improvement in overall acne severity, especially for individuals with moderate to severe acne. Divergent responses to fish oil in our pilot study indicates that dietary and supplemental lipids are worthy of further investigation in acne.

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