2014
DOI: 10.1007/s13197-014-1329-3
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Abstract: Amyloid-beta (Abeta) protein is a key factor in the pathogenesis of Alzheimer's disease (AD). Moreover, it has been reported that oxidative stress is involved in the biochemical pathway by which Abeta can lead to neuronal dysfunction. Recently, docosahexaenoic acid (DHA; C22:6) and eicosapentaenoic acid (EPA; C20:5n-3) have been reported to protect against AD. However, these omega-3 fatty acids are frequently obtained from fish oil and may contain heavy metals. In this study, we utilized Nannochloropsis oceani… Show more

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Cited by 13 publications
(5 citation statements)
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“…Nonetheless, EPA was found in significant high abundances in other microalgae, particularly in N. oceanica , which lacks ALA. In line with our results, previous studies reported a total absence of ALA and high abundances of EPA [ 77 , 78 , 79 , 80 , 81 , 82 ]. One study reported the presence of negligible amounts of ALA; however, the authors were evaluating the effects of the use of phytohormones and nitrogen depletion on biomass and lipid production, which might justify the presence of negligible amounts of this FA in N. oceanica [ 83 ].…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Nonetheless, EPA was found in significant high abundances in other microalgae, particularly in N. oceanica , which lacks ALA. In line with our results, previous studies reported a total absence of ALA and high abundances of EPA [ 77 , 78 , 79 , 80 , 81 , 82 ]. One study reported the presence of negligible amounts of ALA; however, the authors were evaluating the effects of the use of phytohormones and nitrogen depletion on biomass and lipid production, which might justify the presence of negligible amounts of this FA in N. oceanica [ 83 ].…”
Section: Discussionsupporting
confidence: 93%
“…Nonetheless, EPA was found in significant high abundances in other microalgae, particularly in N. oceanica, which lacks ALA. In line with our results, previous studies reported a total absence of ALA and high abundances of EPA [77][78][79][80][81][82].…”
Section: Discussionsupporting
confidence: 93%
“…Similar results have been demonstrated by administering other types of fatty-acid, such as eicosapentaenoic acid (EPA) [127].…”
Section: The Effect Of Fatty-acids On Membrane Fluiditysupporting
confidence: 70%
“…There are limited reports on the protective effects of microalgal extracts against β-secretase inhibition and Aβ-aggregation. Nannochloropsis ocaenia extract protected neuronal cells against Aβ-induced toxicity [ 148 ]. N. ocaenia extract also inhibited Aβ-induced oxidative stress and elevated SOD, GSH and CAT levels in neuro-2A neuroblastoma cells.…”
Section: Neuroprotective Potentials Of Microalgae Against Alzheimementioning
confidence: 99%