Olive leaf powder prevents nonalcoholic steatohepatitis in Sprague–Dawley rats fed a high-fat and high-cholesterol diet

Omagari, Katsuhisa; Koba, Chiaki; Nagata, Asuka; Ngo, Linh; Yamasaki, Mayu; Fukuda, Atsushi; Yuasa, Masahiro; Suruga, Kazuhito; Inada, N; Ichimura‐Shimizu, Mayuko; Tsuneyama, Koichi

doi:10.1016/j.nutos.2021.04.002

Cited by 4 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wren-Dail et al reported that blood glucose concentrations in the SD rats received anesthesia with isoflurane were significantly higher (1836 3 mg/dL) than those received brief CO2 anesthesia (1326 2 mg/dL) (15). Indeed, the blood glucose level after 8 h of fasting in the SD rats received anesthesia with isoflurane and pentobarbital at 18 wk of age was 186.16 9.0 mg/dL in our previous study (16). Therefore, the N group can be considered as con-trol group in the present study, but the better method of anesthesia or euthanasia by decapitation which does not affect the blood glucose metabolism should be used in the future study.…”

Section: Discussionmentioning

confidence: 88%

The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis

OMAGARI,

MARUTA,

YAYAMA

et al. 2023

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

Nonalcoholic steatohepatitis (NASH) can progress to hepatic fibrosis, and is associated with cardiovascular and liver-related mortality. To understand the pathogenesis of NASH, reliable animal models of the disease are useful. In animal studies, the animals are usually fasted overnight before biospecimens are taken, but little is known about the effects of fasting. Here, we investigated the impact of overnight fasting for approximately 9 to 17 h on glucose and lipid metabolism in a Sprague-Dawley (SD) rat model of diet-induced moderate and advanced NASH in comparison to normal SD rats. Our results revealed that in the moderate NASH model rats, the fasting duration did not affect glucose and lipid metabolism, the histopathological findings, or the hepatic mRNA expression levels of genes related to lipid metabolism, cholesterol metabolism, inflammation, fibrosis, and oxidative stress. In contrast, in the normal rats, significant fasting time-dependent reductions were observed in the epididymal fat pad weight and the hepatic mRNA expression levels of adipose differentiation-related protein and heme oxygenase-1. Moreover, in the advanced NASH model rats, a significant fasting time-dependent reduction and increase were observed in the serum insulin level and mRNA expression level of alpha-smooth muscle actin, respectively. Our present results suggest that the influence of the overnight fasting duration differs among the healthy condition, moderate NASH, and advanced NASH statuses. Further studies are needed in humans to determine the appropriate overnight fasting duration for the accurate evaluation of glucose and lipid metabolism in NASH patients.

show abstract

Section: Discussionmentioning

confidence: 88%

The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis

OMAGARI,

MARUTA,

YAYAMA

et al. 2023

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

show abstract

“…If the glycosidic bond is broken, glucose is released, and oleuropein aglycone, with the help of water, is quickly converted into the dialdehyde form of decarboxymethyl oleanolate acid (21). Numerous crucial parameters, such as pH, the type of organic acid and time, as well as combinations of these factors, related to the quantity of purification of hydroxytyrosol isolates, affect the hydrolysis of oleuropein to hydroxytyrosol (22). Various methods for the isolation of oleuropein (Table 1) and hydroxytyrosol (Table 2) have been developed, including standard and modified versions.…”

Section: Characteristics and Extraction Methods Of Oleuropein And Hyd...mentioning

confidence: 99%

Oleuropein and Hydroxytyrosol as Antidiabetics: A Review on Extraction Method, Effectiveness and Toxicity Effect

Harun,

Ketut Adnyana,

Damayanti

et al. 2023

Mil. Med. Sci. Lett.

View full text Add to dashboard Cite

Introduction: Olive (Olea uropeae) is a traditional plant containing oleuropein and hydroxytyrosol, which are useful and used empirically for treating diabetes mellitus.Objective: To review the potential of oleuropein and hydroxytyrosol as an evidence base for diabetes potential treatment and safety. Methods: This chapter summarizes several studies available on Pubmed and Google Scholar regarding the characteristic method and extraction method as well as the effectiveness and toxicity of oleuropein and hydroxytyrosol in vitro and in vivo. Result: Oleuropein and hydroxytyrosol are effective antihyperglycemics for treating T2D. They can reduce body weight, basal glycemia, and insulin resistance by stopping the liver from making glucose and stopping the body from absorbing glucose. Several studies have shown that both isolates can control glycemic levels equivalent to free fatty acids and are safe to use. Conclusion:Oleuropein and hydroxytyrosol are extracted by several methods and can be used as potential anti-diabetics with obesity risk factors. Evidence shows that both isolates are safe for both acute and chronic use.

show abstract

Role of Ethnomedicinal Resources to Cure Metabolic Diseases

Bhattacharjee,

Banerjee

2024

Interdisciplinary Biotechnological Advances

View full text Add to dashboard Cite

Olive leaf powder prevents nonalcoholic steatohepatitis in Sprague–Dawley rats fed a high-fat and high-cholesterol diet

Cited by 4 publications

References 32 publications

The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis

The Effects of Overnight Fasting Duration on Glucose and Lipid Metabolism in a Sprague-Dawley Rat Model of Nonalcoholic Steatohepatitis with Advanced Fibrosis

Oleuropein and Hydroxytyrosol as Antidiabetics: A Review on Extraction Method, Effectiveness and Toxicity Effect

Role of Ethnomedicinal Resources to Cure Metabolic Diseases

Contact Info

Product

Resources

About