Oligonol ameliorates liver function and brain function in the 5 × FAD mouse model: transcriptional and cellular analysis

Jo, Danbi; Arjunan, Archana; Choi, Seoyoon; Jung, Yoon Seok; Park, Jihyun; Jo, Jihoon; Kim, Oh Yoen; Song, Juhyun

doi:10.1039/d3fo03451h

Food Funct.

2023

DOI: 10.1039/d3fo03451h

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Oligonol ameliorates liver function and brain function in the 5 × FAD mouse model: transcriptional and cellular analysis

Danbi Jo,

Archana Arjunan,

Seoyoon Choi

et al.

Abstract: 5 × FAD Alzheimer's disease male mice were treated orally with oligonol at a daily dose of 50 mg kg−1 for 8 weeks. Oligonol oral treatment was found to improve cognitive function, and to reduce anxiety and depression in 5 × FAD Alzheimer's disease mouse.

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2024

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Cited by 2 publications

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Oligonol enhances brain cognitive function in high-fat diet-fed mice

Choi,

Ahn,

et al. 2024

Biomedicine & Pharmacotherapy

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Oligonol enhances brain cognitive function in high-fat diet-fed mice

Choi,

Ahn,

et al. 2024

Biomedicine & Pharmacotherapy

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The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections

Kombe Kombe,

Fotoohabadi,

Nanduri

et al. 2024

IJMS

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Respiratory viruses constitute a significant cause of illness and death worldwide. Respiratory virus-associated injuries include oxidative stress, ferroptosis, inflammation, pyroptosis, apoptosis, fibrosis, autoimmunity, and vascular injury. Several studies have demonstrated the involvement of the nuclear factor erythroid 2-related factor 2 (Nrf2) in the pathophysiology of viral infection and associated complications. It has thus emerged as a pivotal player in cellular defense mechanisms against such damage. Here, we discuss the impact of Nrf2 activation on airway injuries induced by respiratory viruses, including viruses, coronaviruses, rhinoviruses, and respiratory syncytial viruses. The inhibition or deregulation of Nrf2 pathway activation induces airway tissue damage in the presence of viral respiratory infections. In contrast, Nrf2 pathway activation demonstrates protection against tissue and organ injuries. Clinical trials involving Nrf2 agonists are needed to define the effect of Nrf2 therapeutics on airway tissues and organs damaged by viral respiratory infections.

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Oligonol ameliorates liver function and brain function in the 5 × FAD mouse model: transcriptional and cellular analysis

Abstract: 5 × FAD Alzheimer's disease male mice were treated orally with oligonol at a daily dose of 50 mg kg−1 for 8 weeks. Oligonol oral treatment was found to improve cognitive function, and to reduce anxiety and depression in 5 × FAD Alzheimer's disease mouse.

Cited by 2 publications

References 161 publications

Oligonol enhances brain cognitive function in high-fat diet-fed mice

Oligonol enhances brain cognitive function in high-fat diet-fed mice

The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections

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