Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

Paredes, Isidora; Vieira, José Ricardo dos Santos; Shah, Bhavin; Ramunno, Carla F; Dyckow, Julia; Adler, Heike; Richter, Melanie; Schermann, Géza; Giannakouri, Evangelia; Schirmer, Lucas; Augustin, Hellmut G.; Almodóvar, Carmen Ruiz de

doi:10.1038/s41593-020-00788-z

Cited by 24 publications

(24 citation statements)

References 48 publications

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“…It is very interesting from an evolutionary perspective that vasculature not only provides the scaffold for OPC migration immediately following their specification, but also seems to be a critical regulator of initial OPC specification itself (Paredes et al., 2021). Recent work has identified a bidirectional crosstalk between the neural and vascular compartments of the developing CNS around the time of OPC specification.…”

Section: Mechanisms Of Opc Dispersal: Engagement Of the Vasculaturementioning

confidence: 99%

“…Neural progenitor cells (NPCs) express angiopoietin‐1 under the regulation of Sonic hedgehog, which signals to its receptor, Tie2, on endothelial cells to induce the production of transforming growth factor beta 1 (TGFβ1). This endothelial‐derived TGFβ1, then in turn, signals back to NPCs to induce their commitment toward OPC specification (Paredes et al., 2021).…”

Section: Mechanisms Of Opc Dispersal: Engagement Of the Vasculaturementioning

confidence: 99%

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Mechanisms of oligodendrocyte progenitor developmental migration

Xia

Fancy

2021

Developmental Neurobiology

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Oligodendrocytes, the myelinating cells of the central nervous system (CNS), develop from oligodendrocyte progenitor cells (OPCs) that must first migrate extensively throughout the developing brain and spinal cord. Specified at particular times from discrete regions in the developing CNS, OPCs are one of the most migratory of cell types and disperse rapidly. A variety of factors act on OPCs to trigger intracellular changes that regulate their migration. We will discuss factors that act as long‐range guidance cues, those that act to regulate cellular motility, and those that are critical in determining the final positioning of OPCs. In addition, recent evidence has identified the vasculature as the physical substrate used by OPCs for their migration. Several new findings relating to this oligodendroglial–vascular signaling axis reveal new insight on the relationship between OPCs and blood vessels in the developing and adult brain.

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Section: Mechanisms Of Opc Dispersal: Engagement Of the Vasculaturementioning

confidence: 99%

Section: Mechanisms Of Opc Dispersal: Engagement Of the Vasculaturementioning

confidence: 99%

Mechanisms of oligodendrocyte progenitor developmental migration

Xia

Fancy

2021

Developmental Neurobiology

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“…This computational analysis showed that there are certain aging-induced changes in cell-cell communication, including those triggering excessive proinflammatory responses, that were reversed in the old heterochronic parabionts and/or potentiated in the young heterochronic parabionts. As an example, we detailed interactions involving ECs, which are known to secrete signals that regulate neurogenesis 82 and recently were reported to be implicated in signaling networks with OLG lineage cells 83 . When the interactions among EC ligands and their putative cognate receptors in OLG and NRP were explored, we delineated a clear pattern of connection direction reversal between aging and RJV for most ligands, as well as between RJV and AGA, with AGA exhibiting a direction similar to aging (Supplementary Fig 10).…”

Section: Resultsmentioning

confidence: 99%

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Ximerakis

Holton

Giadone

et al. 2022

Preprint

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Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decline are modifiable or even reversible. To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains following parabiosis. For each cell type, we catalogued alterations in gene expression, molecular pathways, transcriptional networks, ligand-receptor interactions, and senescence status. Our analyses identified gene signatures demonstrating that heterochronic parabiosis regulates several hallmarks of aging in a cell-type-specific manner. Brain endothelial cells were found to be especially malleable to this intervention, exhibiting dynamic transcriptional changes that affect vascular structure and function. These findings suggest novel strategies for slowing deterioration and driving regeneration in the aging brain through approaches that do not rely on disease-specific mechanisms or actions of individual circulating factors.

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“…Interactions between migrating glial progenitors from the subventricular zone (SVZ) and growing blood vessels have been recognized long ago in the developing cortex [ 60 ], coinciding with morphological differentiation into astrocytes. During development, a cross-talk between neural progenitor cells (NPCs) and endothelial cells was shown to be crucial for inducing the commitment of NPCs towards OPCs during embryonic development [ 61 ]. In addition, it could be shown that OPCs use the vasculature for guidance during developmental migration, possibly coordinated with differentiation via the Wnt signaling pathway [ 62 ].…”

Section: Oligodendrocyte Precursor Cells (Opcs)mentioning

confidence: 99%

Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease

Pfeiffer

2022

Cells

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Oligodendrocyte precursor cells (OPCs) are mostly known for their capability to differentiate into oligodendrocytes and myelinate axons. However, they have been observed to frequently interact with cells of the neurovascular unit during development, homeostasis, and under pathological conditions. The functional consequences of these interactions are largely unclear, but are increasingly studied. Although OPCs appear to be a rather homogenous cell population in the central nervous system (CNS), they present with an enormous potential to adapt to their microenvironment. In this review, it is summarized what is known about the various roles of OPC-vascular interactions, and the circumstances under which they have been observed.

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Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

Cited by 24 publications

References 48 publications

Mechanisms of oligodendrocyte progenitor developmental migration

Mechanisms of oligodendrocyte progenitor developmental migration

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Reciprocal Interactions between Oligodendrocyte Precursor Cells and the Neurovascular Unit in Health and Disease

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