Olfactory Neuroblastoma: Chemotherapy and Radiotherapy for Extensive Disease

Esthesioneuroblastoma presenting with proptosis and bilateral neck metastasis: An unusual presentation

“…[ 21 ] The role of systemic chemotherapy in the treatment of ENB range from no response,[ 21 ] palliation,[ 20 23 ] partial[ 7 ] or complete response. [ 25 ] In general, chemotherapy is usually reserved for tumor spreading beyond the nasal cavity and paranasal sinuses,[ 17 ] or in the treatment of distant metastases. [ 23 ]…”

Esthesioneuroblastoma Treated with Non-Craniofacial Resection Surgery Followed by Combined Chemotherapy and Radiotherapy: An Alternative Approach in Limited Resources

“…Traditionally, chemotherapy has been reserved for unresectable, recurrent or metastatic disease. The role of chemotherapy as part of combined modality in the standard treatment of ENB is thus still investigational, but some of the latest series have shown promising results (16,18,(20)(21)(22)25,26). Recently a non-surgical approach has also been tried with some success where two cycles of neoadjuvant chemotherapy with cisplatin and etoposide was followed by proton beam radiotherapy (18).…”

Esthesioneuroblastoma: The Johns Hopkins experience

“…Numerous protocols have been described. [25][26][27]31,45 Favorable responses have been reported with cisplatin-based therapies. 26,45 Furthermore, a prospective study of nine patients using cisplatin and etoposide in combination with stereotactic radiation therapy reported significant clinical responses.…”