Olfactory function in acute traumatic brain injury

Frasnelli, Johannes; Laguë-Beauvais, Maude; LeBlanc, Joanne; Alturki, Abdulrahman Y.; Champoux, Marie-Claude; Couturier, Céline; Anderson, Kirsten; Lamoureux, Julie; Marcoux, Judith; Tinawi, Simon; Dagher, Jehane H.; Maleki, Mohammed; Feyz, Mitra; Guise, Élaine de

doi:10.1016/j.clineuro.2015.11.013

Cited by 30 publications

(17 citation statements)

References 43 publications

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“…6,7 In part due to such differences in classification, as well as marked differences between the tests, the incidence of OD is unclear and ranges between 4-60%. [8][9][10][11] Previous studies of OD differ considerably in methodology. This is particularly marked with regards to the recruitment of subjects.…”

Section: Introductionmentioning

confidence: 99%

The incidence of anosmia after traumatic brain injury: the SHEFBIT cohort

et al. 2018

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Section: Introductionmentioning

confidence: 99%

The incidence of anosmia after traumatic brain injury: the SHEFBIT cohort

et al. 2018

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“…testu Sniffin' Sticks lub University of Pennsylvania Smell Identification Test (UPSIT)] zaburzeń sprawności węcho-wej. Bardzo ważne jest stosowanie obiektywnych metod testowych, a nie poleganie na samoocenie pacjentów, gdyż jest ona nierzetelna [2,3] i bardziej związana z odczuciem drożności górnych dróg oddechowych niż rzeczywistą sprawnością węchową [4]. W przypadku potwierdzenia obecności takich zaburzeń kolejnym objawem zwiększa-jącym prawdopodobieństwo procesu neurozwyrodnieniowego jest brak świadomości zaburzeń.…”

Section: Age-related Olfactory Ability Lossunclassified

“…Sniffin' Sticks or UPSITUniversity of Pennsylvania Smell Identification Test). It is very important to employ objective psychometrically validated methods and not to rely only on the patients' self-evaluation due to it not being reliable [2,3] and more associated with upper respiratory tract patency rather than with the actual olfactory ability [4]. When the presence of the aforementioned dysfunction is confirmed, another symptom -which increases the probability of a neurodegenerative process -is a lack of awareness of an olfactory deficit.…”

Section: Wstępmentioning

confidence: 99%

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Śmigórska¹,

Śmigórski²

2017

ppn

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Purpose: The aim of this article is to provide a summary of findings concerning olfactory loss associated with pathological neurodegenerative changes which occur over the course of Alzheimer's disease. Views: It is shown that compared with the healthy population, olfactory dysfunction is more pronounced in neurodegenerative diseases and precedes symptoms typical of those diseases. One of the primary differences between physiological, age-associated and pathological olfactory loss is the patients' awareness of the deficit. Healthy hyposmic or even anosmic patients are often aware of the problems caused by this dysfunction; however, it is not the case for patients in the preclinical, prodromal or clinical stages of Alzheimer's disease. Conclusions:The clinical value of olfactory function assessments should be emphasized, as it may provide information about the potential prodromal symptoms of Alzheimer's disease. Key words: Alzheimer's disease, olfaction disorders, olfactory perception, dementia, smell. StreszczenieCel: Celem pracy jest przedstawienie stanu wiedzy na temat utraty sprawności węchowej związanej z patologicznymi zmianami neurozwyrodnieniowymi zachodzącymi w przebiegu choroby Alzheimera. Poglądy: Przedstawiono dane wskazujące, że u osób cierpiących na choroby neurozwyrodnieniowe zaburzenia sprawności węcho-wej są bardziej nasilone w porównaniu ze zdrową populacją i poprzedzają objawy typowe dla tych chorób. Jedną z głównych różnic między fizjologiczną, związaną z wiekiem a patologiczną utratą węchu jest świadomość deficytu. Zdrowi, hipozmiczni lub nawet anozmiczni pacjenci są często świadomi problemów powodowanych przez dysfunkcję węchową, czego często nie stwierdza się w przypadku pacjentów w przedklinicznym, prodromalnym lub klinicznym stadium choroby Alzheimera.Wnioski: Podkreślono wartość kliniczną badania sprawności węchu jako potencjalnego objawu prodromalnego choroby Alzheimera. Słowa kluczowe: choroba Alzheimera, zaburzenia węchu, percepcja olfaktoryczna, otępienie, węch.

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“…The GOAT is widely used standard measure to assess of PTA. 10,14 GOAT assessment is a good measure to anticipate functional outcome and psychosocial variations. 11,14 There is a paucity of clinical data regarding the prevalence of the PTA after mild TBI in Pakistan.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Post Traumatic Amnesia after Mild Closed Traumatic Brain Injury by Galveston Orientation and Amnesia Test

et al. 2019

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Objective: We evaluated the frequency of post traumatic amnesia (PTA) in close mild traumatic brain injury (TBI) via. Galveston Orientation and Amnesia Test (GOAT).Materials & Methods: A total of 115 patients with mild TBI, both male and female, aged between 14 to 60 years and presenting within the first 6 hours were included. Assessment with the GOAT was performed within 6 hours of admission. Post traumatic amnesia was recorded.Results: Patients’ mean age was 39.21 years. Majority of the patients (64.34%) were between 36- 60 years of age. Prevalence of post traumatic amnesia (PTA) in closed mild TBI was found in 27.83% patients, whereas, there was no post traumatic amnesia in 72.17% patients. Mean admission GCS was 14.54 and the mean GOAT score was 83.89 in all patients GCS 14/15. There was more prevalence of PTA in age 36-60 years, in male patients and “time since injury” in >3 hours. Mean GOAT was 68.3 in patients (30.19%) with PTA with GCS 14, whereas, mean GOAT was 74.8 in patients (25.80%) with PTA with GCS 15.Conclusion: 30.19% patients with GCS 14, were positive for PTA (GOAT: 68.3). Overall, 28% patients were positive for PTA. This study concluded that prevalence of post traumatic amnesia in mild TBI is relatively high in our study as compared to other recent reports.Abbreviations: TBI: Traumatic Brain Injury. PTA: Post Traumatic Amnesia. GOAT: Galveston Orientation and Amnesia Test. GCS: Glaucoma Outcome Scale. LOC: Loss of Consciousness. CT: Computed Tomography.

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Olfactory function in acute traumatic brain injury

Cited by 30 publications

References 43 publications

The incidence of anosmia after traumatic brain injury: the SHEFBIT cohort

The incidence of anosmia after traumatic brain injury: the SHEFBIT cohort

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Prevalence of Post Traumatic Amnesia after Mild Closed Traumatic Brain Injury by Galveston Orientation and Amnesia Test

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