Biochemical Pharmacology volume 77, issue 7, P1273-1282 2009 DOI: 10.1016/j.bcp.2008.12.028 View full text
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Scott A. Reisman, Lauren M. Aleksunes, Curtis D. Klaassen

Abstract: AbstractOleanolic acid is a plant-derived triterpenoid, which protects against various hepatotoxicants in rodents. In order to determine whether oleanolic acid activates nuclear factor erythroid-2 related factor 2 (Nrf2), a transcription factor known to induce various antioxidant and cytoprotective genes, wild-type and Nrf2-null mice were treated with oleanolic acid (90 mg/kg, i.p.) once daily for three days. Oleanolic acid increased nuclear accumulation of Nrf2 in wild-type but not Nrf2-null mice, as determi…

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