Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation

Cardoso, Armando; Silva, Diogo; Magano, Sara; Pereira, Pedro; Andrade, José Paulo

doi:10.1007/s11357-014-9737-x

Cited by 14 publications

(7 citation statements)

References 78 publications

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“…These inhibitory neurons expressing PV and SOM, among the most affected populations impacted by aging in the hippocampus (26,27,31,59,60), have been shown to play important roles in learning and memory operations (28)(29)(30)(31)61). As our memory-guided learning task plausibly engages hippocampal processes, the positive changes recorded in inhibitory neuronal populations presumably reflect the fact that our simple form of training has induced physical and functional changes that have had positive, generalized impacts expressed very broadly across forebrain networks.…”

Section: Discussionmentioning

confidence: 91%

“…The behavioral task applied in the current study required animals to identify a remembered target stimulus presented against a background of nontarget (distracting) stimuli. Inhibitory interneurons expressing PV and SOM in the hippocampus are among the most affected cell populations impacted by aging (26,27) and have long been argued to play critical roles in learning and memory (28)(29)(30)(31). Here we asked if our memory-based go/no-go training task applied in young adulthood detectably impacted the status of these key neuronal populations in the dentate gyrus (DG) and the CA1 subfield of the hippocampus.…”

Section: Resultsmentioning

confidence: 99%

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Positive impacts of early auditory training on cortical processing at an older age

Cheng

Jia

Zhang

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Progressive negative behavioral changes in normal aging are paralleled by a complex series of physical and functional declines expressed in the cerebral cortex. In studies conducted in the auditory domain, these degrading physical and functional cortical changes have been shown to be broadly reversed by intensive progressive training that improves the spectral and temporal resolution of acoustic inputs and suppresses behavioral distractors. Here we found older rats that were intensively trained on an attentionally demanding modulation-rate recognition task in young adulthood substantially retained training-driven improvements in temporal rate discrimination abilities over a subsequent 18-mo epoch-that is, forward into their older age. In parallel, this young-adult auditory training enduringly enhanced temporal and spectral information processing in their primary auditory cortices (A1). Substantially greater numbers of parvalbumin-and somatostatin-labeled inhibitory neurons (closer to the numbers recorded in young vigorous adults) were recorded in the A1 and hippocampus in old trained versus untrained age-matched rats. These results show that a simple form of training in young adulthood in this rat model enduringly delays the otherwise expected deterioration of the physical status and functional operations of the auditory nervous system, with evident training impacts generalized to the hippocampus.aging | auditory cortex | behavioral training | cortical processing | inhibition A degradation of the status of physical brain machinery, expressed by a decline in its temporal processing abilities, has been repeatedly associated with its deteriorating functional status in normal aging (1-4). Recent studies have shown that the machinery that supports processing accuracy and speed, as well as the processes supporting attention control and distractor suppression, can be substantially rejuvenated via simple forms of intensive training in the aged-rat model (4, 5). With auditory perceptual training, in parallel with recovery in behavioral abilities to that matching young-animal performance levels, serials of key physical, chemical, and functional aspects of cortical processing machinery in the trained rats were shown to be restored to a physical or functional status that approached that normally recorded in vigorous young-adult animals.In human studies, substantial changes in speed of processing (SOP) and in other spectro-temporal (or spatiotemporal) signal resolution of performance abilities have been shown to result from attention-demanding, speed-challenged auditory (3, 5-7) or visual training (8-11). For example, the accurate behavioral identification and stimulus-order reconstruction of rapidly successive auditory stimuli was restored in human individuals trained in their eighth decade of life to a performance level normally typifying human performance abilities recorded in their third or fourth decade (3, 6).Our goal here was to define the magnitude and endurance of an intense dose of attention-demanding modulation di...

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Section: Discussionmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Positive impacts of early auditory training on cortical processing at an older age

Cheng

Jia

Zhang

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Quintas et al reported that late-life CR increased SIRT1 in rat hippocampus (Quintas et al, 2012). Cardoso et al found that 18-mo old rats subjected to CR for 6 mo exhibited some protection against age-related decline in neuropeptide Y (NPY)-and somatostatin (SS)-containing neurons in the hippocampus (Cardoso et al, 2014). …”

Section: At What Age Does Cr No Longer Produce Benefits?mentioning

confidence: 99%

Calorie restriction in rodents: Caveats to consider

Ingram

Cabo

2017

Ageing Research Reviews

102

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The calorie restriction paradigm has provided one of the most widely used and most useful tools for investigating mechanisms of aging and longevity. By far, rodent models have been employed most often in these endeavors. Over decades of investigation, claims have been made that the paradigm produces the most robust demonstration that aging is malleable. In the current review of the rodent literature, we present arguments that question the robustness of the paradigm to increase lifespan and healthspan. Specifically, there are several questions to consider as follows: (1) At what age does CR no longer produce benefits? (2) Does CR attenuate cognitive decline? (3) Are there negative effects of CR, including effects on bone health, wound healing, and response to infection? (4) How important is schedule of feeding? (5) How long does CR need to be imposed to be effective? (6) How do genotype and gender influence CR? (7) What role does dietary composition play? Consideration of these questions produce many caveats that should guide future investigations to move the field forward.

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“…injection is better tolerated during long periods of time (2 months) and using high doses (300 mg/kg). 17,24 We focused the present study on the hippocampal formation (HF), a brain limbic region particularly affected by aging [25][26][27][28][29] and presenting the hallmarks of neuronal agerelated deterioration. 14,16 Furthermore, because d-galactose may interfere with neurogenesis, 9,30 we decided to analyze the effects of the high-dose d-galactose on the neurogenesis of the hippocampal dentate granule cells using two neurogenic markers, doublecortin (DCX) and Ki-67, that are easily quantified in young rodents.…”

Section: Introductionmentioning

confidence: 99%

d-Galactose High-Dose Administration Failed to Induce Accelerated Aging Changes in Neurogenesis, Anxiety, and Spatial Memory on Young Male Wistar Rats

Cardoso

Magano

Marrana

et al. 2015

Rejuvenation Research

Self Cite

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The model of accelerated senescence with the prolonged administration of d-galactose is used in anti-aging studies because it mimics several aging-associated alterations such as increase of oxidative stress and decline of cognition. However, there is no standardized protocol for this aging model, and recently some reports have questioned its effectiveness. To clarify this issue, we used a model of high-dose d-galactose on 1-month-old male Wistar rats and studied the hippocampus, one of the most affected brain regions. In one group (n = 10), d-galactose was daily administered intraperitoneally (300 mg/kg) during 8 weeks whereas age-matched controls (n = 10) were injected intraperitoneally with saline. A third group (n = 10) was treated with the same dose of d-galactose and with oral epigallocatechin-3-gallate (EGCG) (2 grams/L), a green tea catechin with anti-oxidant and neuroprotective properties. After treatments, animals were submitted to open-field, elevated plus-maze and Morris water maze tests, and neurogenesis in the dentate gyrus subgranular layer was quantified. There were no significant alterations when the three groups were compared in the number of doublecortin-and Ki-67-immunoreactive cells, and also on anxiety levels, spatial learning, and memory. Therefore, d-galactose was not effective in the induction of accelerated aging, and EGCG administered to d-galactose-treated animals did not improve behavior and had no effects on neurogenesis. We conclude that daily 300 mg/kg of d-galactose administered intraperitoneally may not be a suitable model for inducing age-related neurobehavioral alterations in young male Wistar rats. More studies are necessary to obtain a reliable and reproducible model of accelerated senescence in rodents using d-galactose.

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Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation

Cited by 14 publications

References 78 publications

Positive impacts of early auditory training on cortical processing at an older age

Positive impacts of early auditory training on cortical processing at an older age

Calorie restriction in rodents: Caveats to consider

d-Galactose High-Dose Administration Failed to Induce Accelerated Aging Changes in Neurogenesis, Anxiety, and Spatial Memory on Young Male Wistar Rats

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