OK-432 therapy for lymphangioma in children: Why and how does it work?

Ogita, Shuhei; Tsuto, T.; Nakamura, Kaori; Deguchi, Eiichi; Tokiwa, Kazuyasu; Iwai, Naoharu

doi:10.1016/s0022-3468(96)90478-9

Cited by 215 publications

(164 citation statements)

References 13 publications

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“…Many adjunctive therapies for treatment of lymphangioma have been described with varying results. Successful outcomes have been reported following the use of intralesional Bleomycin, sclerotherapy with OK432 or percutaneous embolization with Ethibloc [15][16][17] . Local injection of fibrin glue and laser photocoagulation have been used for postnatal treatment 18,19 .…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of fetal abdominal lymphangioma by ultrasonography

Deshpande

Twining

O'Neill

2001

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of fetal abdominal lymphangioma by ultrasonography

Deshpande

Twining

O'Neill

2001

Ultrasound in Obstet & Gyne

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“…The streptococcus preparations can activate natural killer cells and T cells, as well as inducing the production of cytokines such as tumor necrosis factor, interleukin-6, vascular endothelial growth factor and transforming growth factor β 1 . Therefore, the intrathoracic injection of these agents promotes the development of fibrin clots, and this is thought to facilitate pleurodes (Ogita et al, 1996;Fujino et al, 2003). Sapylin/OK-432 produces an inflammatory reaction leading to the destruction of the epithelial lining and the subsequent sclerosis and cicatricial contraction of the lesion, too.…”

Section: Discussionmentioning

confidence: 99%

A case of chylothorax treated curatively with Sapylin, a streptococcus preparation

Wang

Zhang

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Chylothorax is an uncommon disease where fatty fluid accumulates within the chest cavity. Conservative management, including repeated thoracentesis or pleurodesis, seems to be suitable to most cases. Herein, we present a case of efficacious pleurodesis by intrapleural injection of Sapylin, a streptococcus preparation, for the treatment of chylothorax. A 52-year-old non-smoking female farmer was diagnosed as idiopathic chylothorax after we ruled out possible causes including chest trauma, lymphoma, lung cancer, filariasis, tuberculosis, and etc. Two-time intra-thoracic injection of 3 Klinische Einheit (KE) Sapylin achieved rapid and effective control of chylothorax with no severe side effects. Sapylin may facilitate pleurodesis by producing a strong inflammatory response.

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“…Ethanol was the most common sclerosing agent used in the past, followed by doxycycline, sodium tetradecyl sulfate (STS), 40 and OK-432. 41 Response varied with the type of lymphatic malformation, with 100%, 86%, and 43% of the patients reporting good to complete response for macrocystic, microcystic, and combined-type lymphatic malformations, respectively.…”

Section: Treatment Of Lymphatic Malformationsmentioning

confidence: 99%

Treatment guideline for hemangiomas and vascular malformations of the head and neck

et al. 2009

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Abstract:Vascular anomalies are among the most common congenital and neonatal dysmorphogenesis, which are separated into hemangiomas and vascular malformations. They can occur in various areas throughout the body, with 60% being located in the head and neck. The true mechanism of pathogenesis of vascular anomalies is still unclear. Various treatment methods have been reported, and there are still controversies over the selection of different treatment modalities. Based on the clinical and basic research and current literature, the Chinese Division of Oral and Maxillofacial Vascular Anomalies formulated a treatment guideline for hemangiomas and vascular malformations of the head and neck, which will be modified and updated periodically based on new medical evidence and research.

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OK-432 therapy for lymphangioma in children: Why and how does it work?

Cited by 215 publications

References 13 publications

Prenatal diagnosis of fetal abdominal lymphangioma by ultrasonography

Prenatal diagnosis of fetal abdominal lymphangioma by ultrasonography

A case of chylothorax treated curatively with Sapylin, a streptococcus preparation

Treatment guideline for hemangiomas and vascular malformations of the head and neck

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