oipA “on” status of Helicobacter pylori is associated with gastric cancer in North-Eastern Brazil

Braga, Lúcia Libanez Bessa Campelo; Batista, Maria Helane Rocha; Azevedo, Orleâncio Gomes Ripardo de; Costa, Kassiane Cristine da Silva; Gomes, Adriana Dias; Rocha, Gifone Aguiar; Queiroz, Dulciene Maria Magalhães

doi:10.1186/s12885-018-5249-x

Cited by 26 publications

(20 citation statements)

References 35 publications

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“…The strains expressing a functional OipA are reportedly involved in bacterial adherence to the gastric epithelial cells with mucosal damage [38] and association with host cell apoptosis [39], interleukin (IL)-8 induction [38], duodenal ulcers [104], and gastric cancer development [105,106]. A study report highlighted the oipA gene’s association with chronic gastritis development.…”

Section: Virulence Factors Associated With Colonization Of Epithelmentioning

confidence: 99%

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari

Yamaoka

2019

Toxins

174

141

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Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world’s population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer. To successfully colonize and establish a persistent infection, the bacteria must overcome harsh gastric conditions. H. pylori has a well-developed mechanism by which it can survive in a very acidic niche. Despite bacterial factors, gastric environmental factors and host genetic constituents together play a co-operative role for gastric pathogenicity. The virulence factors include bacterial colonization factors BabA, SabA, OipA, and HopQ, and the virulence factors necessary for gastric pathogenicity include the effector proteins like CagA, VacA, HtrA, and the outer membrane vesicles. Bacterial factors are considered more important. Here, we summarize the recent information to better understand several bacterial virulence factors and their role in the pathogenic mechanism.

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Section: Virulence Factors Associated With Colonization Of Epithelmentioning

confidence: 99%

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Ansari

Yamaoka

2019

Toxins

174

141

View full text Add to dashboard Cite

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“…Three H. pylori outer membrane proteins (HomB, HopQ, and HopH (OipA)) are associated with gastric cancer [89,90]. The specific outer inflammatory protein antigen (OipA) receptor has not been identified [91].…”

Section: Helicobacter Outer Membrane Proteins and Gastric Cancermentioning

confidence: 99%

Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer

Alipour

2020

J Gastrointest Canc

153

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Introduction Various types of cancers threaten human life. The role of bacteria in causing cancer is controversial, but it has been determined that the Helicobacter pylori infection is one of the identified risk factors for gastric cancer. Helicobacter pylori infection is highly prevalent, and about half of the world , s population is infected with it. Objective The aim of this study was the role of Helicobacter pylori in the development of gastric cancer. Method We obtained information from previously published articles. Results and Conclusion The bacterium has various virulence factors, including cytotoxin-associated gene A, vacuolating cytotoxin A, and the different outer membrane proteins that cause cancer by different mechanisms. These virulence factors activate cell signaling pathways such as PI3-kinase/Akt, JAK/STAT and Ras, Raf, and ERK signaling that control cell proliferation. Uncontrolled proliferation can lead to cancer.

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“…Many studies have suggested that the expression of OipA was positively correlated with PU, GC, and MALT in both Asian and Western strains [50][51][52]. Mahboubi et al inoculated mice with OipA vaccine and the amount of H. pylori colonized in the stomach was significantly reduced, as well as the inflammation after some time.…”

Section: Oipa (Hoph)mentioning

confidence: 99%

Virulence of Helicobacter pylori outer membrane proteins: an updated review

Soyfoo

et al. 2020

Eur J Clin Microbiol Infect Dis

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Helicobacter pylori (H. pylori) infection is associated with some gastric diseases, such as gastritis, peptic ulcer, and gastric cancer. CagA and VacA are known virulence factors of H. pylori, which play a vital role in severe clinical outcomes. Additionally, the expression of outer membrane proteins (OMPs) helps H. pylori attach to gastric epithelial cells at the primary stage and increases the virulence of H. pylori. In this review, we have summarized the paralogs of H. pylori OMPs, their genomic loci, and the different receptors of OMPs identified so far. We focused on five OMPs, BabA (HopS), SabA (HopP), OipA (HopH), HopQ, and HopZ, and one family of OMPs: Hom. We highlight the coexpression of OMPs with other virulence factors and their relationship with clinical outcomes. In conclusion, OMPs are closely related to the pathogenic processes of adhesion, colonization, persistent infection, and severe clinical consequences. They are potential targets for the prevention and treatment of H. pylori-related diseases.

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oipA “on” status of Helicobacter pylori is associated with gastric cancer in North-Eastern Brazil

Cited by 26 publications

References 35 publications

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

Molecular Mechanism of Helicobacter pylori-Induced Gastric Cancer

Virulence of Helicobacter pylori outer membrane proteins: an updated review

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