OIP5-AS1 Attenuates Microangiopathy in Diabetic Mouse by Regulating miR-200b/ACE2

Xie, Wei; Wu, Danni; Ren, Yi; Zhang, Hao; Yang, Song; Sheng, Shiying

doi:10.1016/j.wneu.2020.03.063

Cited by 15 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in multiple myeloma and radioresistant colorectal cancer, OIP5-AS1 was downregulated and played an important role in anti-tumor effects ( 22 ). In addition, current evidence suggested that OIP5-AS1 was related to osteoarthritis ( 23 ), rheumatoid arthritis ( 24 ), primary open angle glaucoma ( 25 ), and diabetes ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

Yan

Zhu

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Coronary artery disease (CAD) is the leading cause of cardiovascular death. The competitive endogenous RNAs (ceRNAs) hypothesis is a new theory that explains the relationship between lncRNAs and miRNAs. The mechanism of ceRNAs in the pathological process of CAD has not been fully elucidated. The objective of this study was to explore the ceRNA mechanism in CAD using the integrative bioinformatics analysis and provide new research ideas for the occurrence and development of CAD.Methods: The GSE113079 dataset was downloaded, and differentially expressed lncRNAs (DElncRNAs) and genes (DEGs) were identified using the limma package in the R language. Weighted gene correlation network analysis (WGCNA) was performed on DElncRNAs and DEGs to explore lncRNAs and genes associated with CAD. Functional enrichment analysis was performed on hub genes in the significant module identified via WGCNA. Four online databases, including TargetScan, miRDB, miRTarBase, and Starbase, combined with an online tool, miRWalk, were used to construct ceRNA regulatory networks.Results: DEGs were clustered into ten co-expression modules with different colors using WGCNA. The brown module was identified as the key module with the highest correlation coefficient. 188 hub genes were identified in the brown module for functional enrichment analysis. DElncRNAs were clustered into sixteen modules, including seven modules related to CAD with the correlation coefficient more than 0.5. Three ceRNA networks were identified, including OIP5-AS1-miR-204-5p/miR-211-5p-SMOC1, OIP5-AS1-miR-92b-3p-DKK3, and OIP5-AS1-miR-25-3p-TMEM184B.Conclusion: Three ceRNA regulatory networks identified in this study may play crucial roles in the occurrence and development of CAD, which provide novel insights into the ceRNA mechanism in CAD.

show abstract

Section: Discussionmentioning

confidence: 99%

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

Yan

Zhu

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…After infection of the olfactory epithelium, SARS-CoV-2 enters the brain via the olfactory nerve and olfactory bulb, according to this hypothesis [ 16 ]. ACE2 is expressed in multiple brain structures including brainstem, cortex, striatum, hypothalamus, and hippocampus [ 17 – 20 ]. Since ACE2 is expressed in neurons and glial cells throughout the brain, it makes both types of cells vulnerable to SARS-CoV-2 [ 19 ].…”

Section: Cellular Mechanisms Of Covid-19 Infectionmentioning

confidence: 99%

The Effect of COVID-19 on NF-κB and Neurological Manifestations of Disease

2021

View full text Add to dashboard Cite

The coronavirus disease that presumably began in 2019 (COVID-19) is a highly infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic. Initially, COVID-19 was thought to only affect respiration. However, accumulating evidence shows a wide range of neurological symptoms are also associated with COVID-19, such as anosmia/ageusia, headaches, seizures, demyelination, mental confusion, delirium, and coma. Neurological symptoms in COVID-19 patients may arise due to a cytokine storm and a heighten state of inflammation. The nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) is a central pathway involved with inflammation and is shown to be elevated in a dose-dependent matter in response to coronaviruses. NF-κB has a role in cytokine storm syndrome, which is associated with greater severity in COVID-19-related symptoms. Therefore, therapeutics that reduce the NF-κB pathway should be considered in the treatment of COVID-19. Neuro-COVID-19 units have been established across the world to examine the neurological symptoms associated with COVID-19. Neuro-COVID-19 is increasingly becoming an accepted term among scientists and clinicians, and interdisciplinary teams should be created to implement strategies for treating the wide range of neurological symptoms observed in COVID-19 patients.

show abstract

“… 14 Interestingly, recent studies also uncovered a close interaction between Ang-(1–7)/MAS1 axis and several lncRNAs. 15 , 16 In view of this evidence, we employed primary astrocytes and APP/PS1 mice to investigate whether lncRNAs were involved in the anti-inflammatory action of Ang-(1–7) during AD progression. It should be noted that Ang-(1–7) has a relatively short duration of biological effect in vivo since it can be rapidly inactivated and degraded by several proteases.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-(1–7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer’s Disease

Duan¹,

Wang²,

Wei³

et al. 2021

JIR

View full text Add to dashboard Cite

Objective Emerging evidence suggests that brain angiotensin-(1–7) (Ang-(1–7)) deficiency contributes to the pathogenesis of Alzheimer’s disease (AD). Meanwhile, our previous studies revealed that restoration of brain Ang-(1–7) levels provided neuroprotection by inhibition of inflammatory responses during AD progress. However, the potential molecular mechanisms by which Ang-(1–7) modulates neuroinflammation remain unclear. Materials and Methods APP/PS1 mice were injected intraperitoneally with AVE0991 (a nonpeptide analogue of Ang-(1–7)) once a day for 30 consecutive days. Cognitive functions, neuronal and synaptic integrity, and inflammation-related markers were assessed. Since astrocytes played a crucial role in AD-related neuroinflammation whilst long noncoding RNAs (lncRNAs) were reported to participate in modulating inflammatory responses, astrocytes of APP/PS1 mice were isolated for high-throughput lncRNA sequencing to identify the most differentially expressed lncRNA following AVE0991 treatment. Afterward, the downstream pathways of this lncRNA in the anti-inflammatory action of AVE0991 were investigated using primary astrocytes. Results AVE0991 rescued spatial cognitive impairments and alleviated neuronal and synaptic damage in APP/PS1 mice. The levels of Aβ 1-42 in the brain of APP/PS1 mice were not affected by AVE0991. By employing high-throughput lncRNA sequencing, our in vitro study demonstrated for the first time that AVE0991 suppressed astrocytic NLRP3 inflammasome-mediated neuroinflammation via a lncRNA SNHG14-dependent manner. SNHG14 acted as a sponge of miR-223-3p while NLRP3 represented a direct target of miR-223-3p in astrocytes. In addition, miR-223-3p participated in the AVE0991-induced suppression of astrocytic NLRP3 inflammasome. Conclusion Our results suggest that Ang-(1–7) analogue AVE0991 inhibits astrocyte-mediated neuroinflammation via SNHG14/miR-223-3p/NLRP3 pathway and offers neuroprotection in APP/PS1 mice. These findings reveal the underlying mechanisms by which Ang-(1–7) inhibits neuroinflammation under AD condition and uncover the potential of its nonpeptide analogue AVE0991 in AD treatment.

show abstract

OIP5-AS1 Attenuates Microangiopathy in Diabetic Mouse by Regulating miR-200b/ACE2

Cited by 15 publications

References 31 publications

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease

The Effect of COVID-19 on NF-κB and Neurological Manifestations of Disease

Angiotensin-(1–7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer’s Disease

Contact Info

Product

Resources

About