Oil-entrapped sterculia gum–alginate buoyant systems of aceclofenac: Development and in vitro evaluation

Floating capsules containing alginate-based beads of salbutamol sulfate: In vitro–in vivo evaluations

“…For optimization, effects of various independent variables upon measured responses were modeled mathematically by 3 2 factorial design [22]:…”

“…The principal rule is almost constant for all techniques, and that is to provide a density lower than the gastric fluids so that they would be capable of those drugs that act locally in the proximal gastrointestinal tract (GIT), are unstable in the lower part of the gastrointestinal tract, or are poorly absorbed in the intestine [20]. In recent years, various oil-entrapped floating beads have been developed [7,8,[21][22][23][24][25][26][27][28]. But, the oral administration of multiple-unit systems is associated with the problem of single dose calculation of drugs at the time of administration.…”

“…Calcium alginate, HPMC K4M and potato starch have the ability of drug release retarding power [1,29]. On the other hand, entrapped low density liquid paraffin and HPMC K4M are capable to produce buoyancy [3,6,[21][22][23].…”

“…Factorial designs are considered the most effective statistical optimization tools in estimating the effects of various formulation variables with minimum experimentation and time, where all factors are studied in all possible combinations by analyzing the influence of individual variables and their interactions using minimum experiments [8,29,36]. Based on the factorial designs, the optimization technique encompasses the generation of model equations for investigated responses over the experimental design to determine the settings of factor values to achieve optimum formulation(s) [22]. In this study, a 3 2 factorial design-based computer-aided optimization was employed to investigate the effects of HPMC K4M and potato starch weight masses as two independent process variables (factors), on the drug encapsulation efficiency of salbutamol sulfate-loaded oil-entrapped multiple-unit beads and salbutamol sulfate release from stomach-specific floating capsules containing salbutamol sulfate-loaded oil-entrapped multiple-unit beads.…”

Floating-Bioadhesive Matrix Tablets of Hydralazine HCL Made of Cashew Gum and HPMC K4m

“…As a result of this, the drug is slowly released at a desired rate which results in an enhanced gastric retention time as well as a better control of the fluctuation in plasma drug concentration and thus, increases the bioavailability. Currently, floatation and bioadhesion approaches are being extensively examined to improve therapeutic efficacy by maximizing bioavailability through gastro retention of the dosage form [19][20][21][22][23][24][25][26][27][28][29]. Recent years, the combination of floatation and bioadhesion approaches has gained importance in the development of gastro retentive drug delivery system [30][31][32][33].…”