2018
DOI: 10.4155/bio-2017-0213
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Abstract: The qualified method was successfully applied to simultaneously measure vanillin and vanillic acid in plasma and urine from a guinea pig pharmacokinetic study.

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Cited by 4 publications
(2 citation statements)
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“…Therefore, it is important to develop a method for the determination of vanillic acid in rat plasma. Literature research suggested that many analytical methods including HPLC (Xu et al, 2007) and LC-MS/MS (Bhutani et al, 2018;Du et al, 2017;Pan et al, 2017;Pang et al, 2016;Tao et al, 2019;Zeng et al, 2016) have been established and applied for the quantitative analysis of vanillic acid. However, these works mainly focused on the pharmacokinetic behavior of vanillic acid after oral administration of Chinese herb extracts.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, it is important to develop a method for the determination of vanillic acid in rat plasma. Literature research suggested that many analytical methods including HPLC (Xu et al, 2007) and LC-MS/MS (Bhutani et al, 2018;Du et al, 2017;Pan et al, 2017;Pang et al, 2016;Tao et al, 2019;Zeng et al, 2016) have been established and applied for the quantitative analysis of vanillic acid. However, these works mainly focused on the pharmacokinetic behavior of vanillic acid after oral administration of Chinese herb extracts.…”
Section: Introductionmentioning
confidence: 99%
“…A GC–MS method for HCA measurement in human plasma has been previously reported (Loe, Bergeron, Rodriguez, & Schwarz, 2001). The described procedure used a complex sample preparation, including derivatization (Bhutani, Murugesan, Kumar, Subramanian, & Prabhakar, 2018; Mao, Zhao, Sun, Lu, & Li, 2019; Santa, 2011). This is a complex multi‐step procedure, which might affect reproducibility of the method.…”
Section: Introductionmentioning
confidence: 99%