Oestrogenic potency of genistin and daidzin in mice

Estrogenic Activity of Glycitein, a Soy Isoflavone

“…The relative estrogenic potencies of DES, glycitein, and genistein were estimated on the basis of the doses required to produce the same increase of uterine weights. The relative estrogenic potencies of genistein and DES from the present study were similar to the results of Farmakalidis and Murphy (1985), who found the relative molar potencies of DES, genistein, genistin, and daidzin to be 100000, 1, 1, and 0.26, respectively. The present study demonstrated that the estrogenic potency of glycitein in mice uterine enlargement assay was 3 times higher than that of genistein, but, as hypothesized, was much lower than that of DES.…”

Estrogenic Activity of Glycitein, a Soy Isoflavone

“…The relative estrogenic potencies of DES, glycitein, and genistein were estimated on the basis of the doses required to produce the same increase of uterine weights. The relative estrogenic potencies of genistein and DES from the present study were similar to the results of Farmakalidis and Murphy (1985), who found the relative molar potencies of DES, genistein, genistin, and daidzin to be 100000, 1, 1, and 0.26, respectively. The present study demonstrated that the estrogenic potency of glycitein in mice uterine enlargement assay was 3 times higher than that of genistein, but, as hypothesized, was much lower than that of DES.…”

The Effect of Soybean Protein on Bone Loss in a Rat Model of Postmenopausal Osteoporosis.

“…The precise mechanism of action of estrogen in the treatment of PMO has not Equol possesses weak estrogenic activity , in the order of 10-3 times that of estradiol (38), while that of genistein is about 10-3 to 10-5 that of estradiol (39). Phytoestrogens have also been reported to produce uterotrophic effects in animals (40), but this was not observed in our study or that of other researchers (14).…”

Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens

“…The uterotropic activity of daidzein has previously been described as low (Farmakalidis et al 1985). Our results indicate that genistein reveals a higher short-term estrogenic potency in vivo than its inactive analog daidzein.…”

Estrogenic Activity of Glycitein, a Soy Isoflavone

“…The relative estrogenic potencies of DES, glycitein, and genistein were estimated on the basis of the doses required to produce the same increase of uterine weights. The relative estrogenic potencies of genistein and DES from the present study were similar to the results of Farmakalidis and Murphy (1985), who found the relative molar potencies of DES, genistein, genistin, and daidzin to be 100000, 1, 1, and 0.26, respectively. The present study demonstrated that the estrogenic potency of glycitein in mice uterine enlargement assay was 3 times higher than that of genistein, but, as hypothesized, was much lower than that of DES.…”

The Effect of Soybean Protein on Bone Loss in a Rat Model of Postmenopausal Osteoporosis.

“…The precise mechanism of action of estrogen in the treatment of PMO has not Equol possesses weak estrogenic activity , in the order of 10-3 times that of estradiol (38), while that of genistein is about 10-3 to 10-5 that of estradiol (39). Phytoestrogens have also been reported to produce uterotrophic effects in animals (40), but this was not observed in our study or that of other researchers (14).…”

Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens

“…The uterotropic activity of daidzein has previously been described as low (Farmakalidis et al 1985). Our results indicate that genistein reveals a higher short-term estrogenic potency in vivo than its inactive analog daidzein.…”

Estrogenic Activity of Glycitein, a Soy Isoflavone

“…The relative estrogenic potencies of DES, glycitein, and genistein were estimated on the basis of the doses required to produce the same increase of uterine weights. The relative estrogenic potencies of genistein and DES from the present study were similar to the results of Farmakalidis and Murphy (1985), who found the relative molar potencies of DES, genistein, genistin, and daidzin to be 100000, 1, 1, and 0.26, respectively. The present study demonstrated that the estrogenic potency of glycitein in mice uterine enlargement assay was 3 times higher than that of genistein, but, as hypothesized, was much lower than that of DES.…”

The Effect of Soybean Protein on Bone Loss in a Rat Model of Postmenopausal Osteoporosis.

“…The precise mechanism of action of estrogen in the treatment of PMO has not Equol possesses weak estrogenic activity , in the order of 10-3 times that of estradiol (38), while that of genistein is about 10-3 to 10-5 that of estradiol (39). Phytoestrogens have also been reported to produce uterotrophic effects in animals (40), but this was not observed in our study or that of other researchers (14).…”

Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens

“…The uterotropic activity of daidzein has previously been described as low (Farmakalidis et al 1985). Our results indicate that genistein reveals a higher short-term estrogenic potency in vivo than its inactive analog daidzein.…”