Oestrogen treatment for tall stature in girls: estimating the effect on height and the error in height prediction

Venn, Alison; Hosmer, Trina; Hosmer, David W.; Bruinsma, Fiona; Jones, Penelope; Lumley, Judith; Pyett, Priscilla; Rayner, Jo-Ann; Werther, George A.

doi:10.1111/j.1365-2265.2007.03128.x

Cited by 20 publications

(9 citation statements)

References 18 publications

(43 reference statements)

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“…Articles with high-dose synthetic EE2 or conjugated estrogens. Height reduction due to treatment with EE2 or conjugated estrogens varies among different studies, and height reductions of 1.4-7.4 cm have been reported (2,(6)(7)(8)(16)(17)(18). Variation in the height reduction achieved with EE2 or conjugated estrogens treatment is probably due to methodological differences.…”

Section: Evaluation Of 293 Tall Statured Girlsmentioning

confidence: 99%

“…Variation in the height reduction achieved with EE2 or conjugated estrogens treatment is probably due to methodological differences. This, differences in BA measurement method, PAH method, BA and chronological age at start of treatment, EE2 doses used and differences in treatment duration may all influence response (2,(6)(7)(8)(16)(17)(18).…”

Section: Evaluation Of 293 Tall Statured Girlsmentioning

confidence: 99%

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Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol

Upners

Juul

2016

Pediatr Res

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Section: Evaluation Of 293 Tall Statured Girlsmentioning

confidence: 99%

Section: Evaluation Of 293 Tall Statured Girlsmentioning

confidence: 99%

Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol

Upners

Juul

2016

Pediatr Res

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“…High-dose estrogen therapy has been documented to effectively reduce adult height in extremely tall girls (Goldzieher, 1956; Venn et al, 2008). However, the long-term effects of such treatment has to be considered.…”

Section: Systemic Regulation Of the Growth Platementioning

confidence: 99%

Genetic Regulation of the Growth Plate

Karimian¹,

Chagin²,

Sävendahl³

2012

Front. Endocrin.

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The epiphyseal growth plate consists of a layer of cartilage present only during the growth period and vanishes soon after puberty in long bones. It is divided to three well-defined zones, from epiphyses; resting, proliferative, and hypertrophic zones. Chondrocyte proliferation and differentiation and subsequent bone formation in this cartilage are controlled by various endocrine, autocrine, and paracrine factors which finally results into elimination of the cartilaginous tissue and promotion of the epiphyseal fusion. As chondrocytes differentiate from round, quiescent, and single structure to flatten and proliferative and then large and terminally differentiated, they experience changes in their gene expression pattern which allow them to transform from cartilaginous tissue to bone. This review summarizes the literature in this area and shortly describes different factors that affect growth plate cartilage both at the local and systemic levels. This may eventually help us to develop new treatment strategies of different growth disorders.

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“…Analysis of pooled data from several studies predict a growth-attenuating effect of 6 Ϯ 1.5 cm at a bone age of 10 years, 3 Ϯ 1.0 cm at a bone age of 12 years, and no effect at a bone age of 14 years. 10 Whether the slope of this regression line can be extrapolated to initiation of treatment at much younger bone ages is not known, but on the basis of height outcomes of children with naturally occurring untreated precocious puberty, it is reasonable to expect a potential growth attenuating effect significantly Ͼ6 cm.…”

Section: Medical Issues/considerationsmentioning

confidence: 99%

Growth-Attenuation Therapy: Principles for Practice

et al. 2009

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Publication of an account of growth attenuation with high-dose estrogen in a child with profound physical and cognitive disability brought widespread attention to a common and complex issue faced by families caring for similarly affected children, namely, the potentially negative effect of the increasing size of a child on the ability of his or her family to provide independent care, which in turn makes it more difficult for parents to keep the child in the home and involved in family activities. In this article we explore the scientific rationale for, effectiveness and safety of, and ethical considerations bearing on growth-attenuation treatment of children with profound and permanent cognitive disability. Informed responses to key clinically relevant questions are proposed. Our analysis suggests that growth attenuation is an innovative and sufficiently safe therapy that offers the possibility of an improved quality of life for nonambulatory children with profound cognitive disability and their families. Pediatricians and other care providers should include discussion of these options as part of anticipatory guidance around the age of 3 years so that, if elected, potential clinically meaningful benefits of growth-attenuation therapy can be realized. Because of the publicity and debate surrounding the first reported case, ethics consultation is recommended.

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Oestrogen treatment for tall stature in girls: estimating the effect on height and the error in height prediction

Abstract: On average, oestrogen treatment resulted in an adult height that was less than predicted. Although treatment was more effective in the least mature girls, the mean height difference was relatively modest for most treated girls.

Cited by 20 publications

References 18 publications

Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol

Evaluation and phenotypic characteristics of 293 Danish girls with tall stature: effects of oral administration of natural 17β-estradiol

Genetic Regulation of the Growth Plate

Growth-Attenuation Therapy: Principles for Practice

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