Ocular Pulse Amplitude in Healthy Subjects as Measured by Dynamic Contour Tonometry

Abstract

To test whether dynamic contour tonometry yields ocular pulse amplitude (OPA) measurements that are independent of corneal thickness and curvature, and to assess variables of observer agreement. Methods: In a multivariate cluster analysis on 223 eyes, the relationship between central corneal thickness, corneal curvature, axial length, anterior chamber depth, intraocular pressure, sex, age, and OPA measurements was assessed. Intraobserver and interobserver variabilities were calculated from repeated measurements obtained from 8 volunteers by 4 observers. Results: The OPA readings were not affected by central corneal thickness (P=.08), corneal curvature (P=.47), anterior chamber depth (P = .80), age (P = .60), or sex (P =.73). There was a positive correlation between OPA and intraocular pressure (0.12 mm Hg/1 mm Hg of intraocular pressure; PϽ.001) and a negative correlation between OPA and axial length (0.27 mm Hg/1 mm of length; PϽ.001). Intraobserver and interobserver variabilities were 0.08 and 0.02 mm Hg, respectively, and the intraclass correlation coefficient was 0.89. Conclusions: The OPA readings obtained with dynamic contour tonometry in healthy subjects are not influenced by the structure of the anterior segment of the eye but are affected by intraocular pressure and axial length. We found a high amount of agreement within and between observers.

The ocular pulse amplitude at different intraocular pressure: a prospective study

“…There may be two underlying reasons: First, we also did not find any correlation between baseline OPA and axial length (Pearson’s r = 0.07, p = 0.66), in contrast to other studies (James et al. 1991; Kaufmann et al. 2006; Berisha et al.…”

The ocular pulse amplitude at different intraocular pressure: a prospective study

“…There may be two underlying reasons: First, we also did not find any correlation between baseline OPA and axial length (Pearson’s r = 0.07, p = 0.66), in contrast to other studies (James et al. 1991; Kaufmann et al. 2006; Berisha et al.…”

Macular Pigment Optical Density and Ocular Pulse Amplitude in Subjects with Different Axial Lengths and Refractive Errors

“…In hyperopia, OPA and IOP are normal. These findings are consistent with the results of Kaufmann et al [13–16]. …”

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

“…We found a significant positive correlation between OPA and IOP in ADAMTS10 -mutant dogs. This finding is consistent with several human studies that found positive correlations between OPA and IOP in healthy individuals and patients with NTG and OHT ( Phillips et al, 1992 ; Kaufmann et al, 2006 ; Kim et al, 2013 ; Sturmer and Kniestedt, 2015 ).…”

The ocular pulse amplitude at different intraocular pressure: a prospective study

“…There may be two underlying reasons: First, we also did not find any correlation between baseline OPA and axial length (Pearson’s r = 0.07, p = 0.66), in contrast to other studies (James et al. 1991; Kaufmann et al. 2006; Berisha et al.…”

Macular Pigment Optical Density and Ocular Pulse Amplitude in Subjects with Different Axial Lengths and Refractive Errors

“…In hyperopia, OPA and IOP are normal. These findings are consistent with the results of Kaufmann et al [13–16]. …”

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

“…We found a significant positive correlation between OPA and IOP in ADAMTS10 -mutant dogs. This finding is consistent with several human studies that found positive correlations between OPA and IOP in healthy individuals and patients with NTG and OHT ( Phillips et al, 1992 ; Kaufmann et al, 2006 ; Kim et al, 2013 ; Sturmer and Kniestedt, 2015 ).…”

The ocular pulse amplitude at different intraocular pressure: a prospective study

“…There may be two underlying reasons: First, we also did not find any correlation between baseline OPA and axial length (Pearson’s r = 0.07, p = 0.66), in contrast to other studies (James et al. 1991; Kaufmann et al. 2006; Berisha et al.…”

Macular Pigment Optical Density and Ocular Pulse Amplitude in Subjects with Different Axial Lengths and Refractive Errors

“…In hyperopia, OPA and IOP are normal. These findings are consistent with the results of Kaufmann et al [13–16]. …”

Ocular pulse amplitude (OPA) in canine ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

“…We found a significant positive correlation between OPA and IOP in ADAMTS10 -mutant dogs. This finding is consistent with several human studies that found positive correlations between OPA and IOP in healthy individuals and patients with NTG and OHT ( Phillips et al, 1992 ; Kaufmann et al, 2006 ; Kim et al, 2013 ; Sturmer and Kniestedt, 2015 ).…”