Ocular psoriasis

Rehal, Balvinder; Modjtahedi, Bobeck S.; Morse, Lawrence S.; Schwab, Ivan R.; Maibach, Howard I.

doi:10.1016/j.jaad.2010.10.032

Cited by 103 publications

(110 citation statements)

References 76 publications

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“…Chandran and his coworkers reported only one ophthalmic abnormality out of 67% patients with psoriasis, whereas 20% of them had more than one abnormality. The present figures seem to be higher as postulated by the authors than would be expected; this could be verified only in the presence of a control group or population-based data for comparison [5].…”

Section: Introductionsupporting

confidence: 52%

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Association between psoriasis and ocular disorders: A narrative review

Algarni¹,

AlMuqrin²,

Alarwan³

2017

Clin Med Invest

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Psoriasis is a long lasting immunological assisted skin disease along with many extra cutaneous manifestations, with substantial genetic and environmental influences. It affects about 1.5-3% of the world's population, though commonly not life threatening, but then again causes significant morbidity and has no remedy. We conducted a systematic search on the sites like Pub Med, Embase, Scopus, and multiple databases. The literature search included MeSH-terms and text words, in the following combination such as Blepharitis, dry eye, psoriasis, uveitis, immunological assisted skin disease. No restrictions were followed in terms of publication dates. The reference lists of included articles were screened for additional references. Psoriatic ocular findings may include conjunctivitis, dry eye, blepharitis, squamous intraepithelial neoplasm of the conjunctiva, corneal abscess and immune-mediated conditions such as uveitis, all of which may lead to articular changes. Its pathogenesis is very complicated and involves many molecules like T cells, APCs, keratinocytes, Langerhans cell, macrophages, NK cells, an array of Th1-type cytokines along with certain growth factors like VEGF, KGF which are instrumental in the development of psoriasis. Moreover, ocular disorders are characterized by a series of interconnected cellular changes in the skin like hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils, and other types of leukocyte in the affected skin. Generally, ocular complications are managed with nonsteroidal anti-inflammatory drugs, corticosteroids, and immunosuppressive agents. Surgical therapy should be carried out, when there are chances of visual disturbance. Timely and correct diagnosis with quick treatment or referral to an ophthalmologist may prevent systemic and ocular disorders. This review highlights the association of psoriasis and ocular disorders with their clinical sign and symptoms.

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Section: Introductionsupporting

confidence: 52%

“…Conjunctival lesions have been described as demarcated, yellowish-red plaques on the palpebral conjunctiva or as areas of xerotic appearance on the bulbar conjunctiva. Conjunctivitis can lead to xerosis, symblepharon, and trichiasis with further complications involving the cornea [5].…”

Section: Pathogenesismentioning

confidence: 99%

Association between psoriasis and ocular disorders: A narrative review

Algarni¹,

AlMuqrin²,

Alarwan³

2017

Clin Med Invest

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“…The prevalence of ophthalmic involvement in patients with cutaneous disease is not known; however, it is thought to occur in approximately 10% of patients. 48 Psoriasis may affect almost any part of the eye, leading to blepharitis, peripheral keratopathy, acute anterior uveitis, posterior synechiae, conjunctivitis, and cataract formation.…”

Section: Natural Historymentioning

confidence: 99%

Psoriasis: epidemiology, natural history, and differential diagnosis

Basko-Plluska¹,

Petronic‐Rosic²

2012

PTT

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Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genomewide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immunemediated, inflammatory disorders.

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“…Ophthalmic complications of psoriasis are numerous and affect almost any part of the eye; however, they may be easily missed. Complications include direct cutaneous effects such as eyelid involvement and blepharitis, and immune mediated conditions such as uveitis (Rehal et al, 2011). In Spain, between January 2007 and December 2009 of a total of 661 patients included, 47.4% were diagnosed with nail psoriasis, which was 13.5% more prevalent in men.…”

mentioning

confidence: 99%

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

O'Daly¹

2012

Psoriasis - A Systemic Disease

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Ocular psoriasis

Cited by 103 publications

References 76 publications

Association between psoriasis and ocular disorders: A narrative review

Association between psoriasis and ocular disorders: A narrative review

Psoriasis: epidemiology, natural history, and differential diagnosis

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

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