2016
DOI: 10.1186/s12917-016-0778-5
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Abstract: BackgroundIt has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of … Show more

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Cited by 2 publications
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“…Several studies have yielded mixed results. Those studies supporting this theory have shown that oral sildenafil can induce changes in choroidal thickness [ 11 , 12 ], vascular flow [ 13 16 ], and alteration in retinal electroretinogram [ 17 ] and others that did not find changes in perimetry [ 18 ], flowmetry [ 19 ], and Doppler echography [ 20 ]. Therefore, the purpose of the current study is to assess vascular changes in the retinal and choroidal circulation, by taking advantage all the capabilities of the OCT-A, after the oral ingestion of sildenafil in healthy volunteers.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have yielded mixed results. Those studies supporting this theory have shown that oral sildenafil can induce changes in choroidal thickness [ 11 , 12 ], vascular flow [ 13 16 ], and alteration in retinal electroretinogram [ 17 ] and others that did not find changes in perimetry [ 18 ], flowmetry [ 19 ], and Doppler echography [ 20 ]. Therefore, the purpose of the current study is to assess vascular changes in the retinal and choroidal circulation, by taking advantage all the capabilities of the OCT-A, after the oral ingestion of sildenafil in healthy volunteers.…”
Section: Introductionmentioning
confidence: 99%