Ocular Mucous Membrane Pemphigoid and Ocular Pemphigus Vulgaris Treated Topically With Tacrolimus Ointment

Hall, Virginia C.; Liesegang, Thomas J.; Kostick, David A.; Lookingbill, Donald P.

doi:10.1001/archderm.139.8.1083

Cited by 48 publications

(19 citation statements)

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“…Ocular presentation in PV is rare; approximately 20 cases have been reported in the English-language literature. [6][7][8][9] In our cohort of 167 patients with PV, the incidence of ocular involvement is approximately 7% (11 patients). Since reports of ocular involvement in other studies are lacking, we are unable to compare our experience with that of others.…”

Section: Discussionmentioning

confidence: 99%

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Ocular pemphigus

Daoud

Cervantes

Foster

et al. 2005

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

“…Ocular involvement in PV has been rarely reported in the literature. [6][7][8][9] Approximately 20 patients with PV have been reported to have ocular disease. The most common presentation in PV is nonscarring conjunctivitis.…”

mentioning

confidence: 99%

Ocular pemphigus

Daoud

Cervantes

Foster

et al. 2005

Journal of the American Academy of Dermatology

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“…Experience in treating ocular disease with topical tacrolimus has been reported. Hall et al and Michel et al reported successful use of topical tacrolimus in the treatment of patients with OCP [39–41]. Lee et al evaluated the therapeutic efficacy of topical tacrolimus in one patient with OCP and 6 cases of Stevens-Johnson syndrome (SJS).…”

Section: Reviewmentioning

confidence: 99%

Topical tacrolimus in anterior segment inflammatory disorders

Shoughy

2017

Eye and Vis

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Immune mediated inflammatory anterior segment diseases are variable and their management requires intense immunosuppression. Treatment with topical steroids is associated with serious ocular side effects. In order to overcome the potentially blinding complications of topical steroids, immunomodulatory drugs are being used more frequently. Tacrolimus is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular inflammation. Tacrolimus was recently investigated for application in various anterior segment inflammatory disorders. In this review, we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation.

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“…It has been proven useful in atopic dermatitis [12]and erosive lichen planus [13]. Recently, Chu et al [14]have reported that tacrolimus ointment was a useful adjunctive therapy in 2 elderly patients with bullous pemphigoid, whereas Hall et al [15]employed tacrolimus ointment in 2 patients suffering from either ocular cicatricial pemphigoid or ocular pemphigus with good local response. Finally, Vecchietti et al [16]successfully controlled a treatment-resistant stomatitis associated with paraneoplastic pemphigus with oral rinses of tacrolimus 0.03%.…”

Section: Discussionmentioning

confidence: 99%

Localized Childhood Vulval Pemphigoid Treated with Tacrolimus Ointment

et al. 2004

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Background: Localized vulval childhood pemphigoid is a rare variant within the pemphigoid group. Although its prognosis seems favorable, the best therapeutic strategy remains unclear. Observation: We here describe the case of an 8-year-old girl presenting with a 5-year history of relapsing vulval pain and lesions suggestive of lichen sclerosus. Clinical features, light microscopy and direct immunofluorescence microscopy were consistent with vulval cicatricial pemphigoid, although the autoantigen(s) involved could not be characterized. Her disease responded to treatment with topical tacrolimus ointment 0.1% within 3 months without any evidence for disease activity, except for slight residual scarring. After 12 months, her treatment was stopped without relapse. Conclusion: This observation suggests that in this rare immune-mediated blistering disease topical tacrolimus is an interesting therapeutic option without the adverse effects associated with topical steroids.

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Ocular Mucous Membrane Pemphigoid and Ocular Pemphigus Vulgaris Treated Topically With Tacrolimus Ointment

Cited by 48 publications

References 1 publication

Ocular pemphigus

Ocular pemphigus

Topical tacrolimus in anterior segment inflammatory disorders

Localized Childhood Vulval Pemphigoid Treated with Tacrolimus Ointment

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